Cannabinoids May Inhibit Cancer Cell Invasion

Main Category: Cancer / Oncology
Also Included In: Alcohol / Addiction / Illegal Drugs
Article Date: 27 Dec 2007 - 1:00 PDT

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Cannabinoids may suppress tumor invasion in highly invasive cancers. Cannabinoids, the active components in marijuana, are used to reduce the side effects of cancer treatment, such as pain, weight loss, and vomiting, but there is increasing evidence that they may also inhibit tumor cell growth. However, the cellular mechanisms behind this are unknown.

Robert Ramer, Ph.D., and Burkhard Hinz, Ph.D., of the University of Rostock in Germany investigated whether and by what mechanism cannabinoids inhibit tumor cell invasion.

Cannabinoids did suppress tumor cell invasion and stimulated the expression of TIMP-1, an inhibitor of a group of enzymes that are involved in tumor cell invasion.

"To our knowledge, this is the first report of TIMP-1-dependent anti-invasive effects of cannabinoids. This signaling pathway may play an important role in the antimetastatic action of cannabinoids, whose potential therapeutic benefit in the treatment of highly invasive cancers should be addressed in clinical trials," the authors write.

"Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1"
Robert Ramer, Burkhard Hinz
JNCI Journal of the National Cancer Institute, doi:10.1093/jnci/djm268
Click here to view abstract online

Andrea Widener
Journal of the National Cancer Institute