The Many Uses For The New Electron Microscope Include Medical Research Into Liver Disease

Main Category: Medical Devices
Also Included In: Biology / Biochemistry
Article Date: 25 Jan 2008 - 4:00 PDT

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A unique electron microscope, the first of its kind in the world, was unveiled yesterday at the STFC Daresbury Laboratory in Warrington. It will enable scientists to study atoms within materials in a way that has never before been possible and will pave the way for pioneering research relating to every aspect of our lives, from research into liver disease, to the creation of the mobile phones and computers of the future. Sponsored by the EPSRC and led by the University of Liverpool, the SuperSTEM 2 has been created by a collaboration of leading scientists from the universities of Liverpool, Glasgow and Leeds and the Daresbury Laboratory.

Atoms are the building blocks of matter and the study of these atoms is known as nanotechnology. The SuperSTEM 2 can show an atom at 20 million times its size. At 20 million times its size an atom would measure approximately 5mm across. To put this into context, if a person were magnified by this much they would be able to hug the Earth! However, it is not just the scale of magnification that makes SuperSTEM 2 unique - it is also the sharpness of the image, its capability to provide elemental and chemical data about atoms and its stability. Built on sandstone bedrock, the incredibly stable geological conditions at the Daresbury Laboratory is one of the key reasons for its location - the system is so stable that any sample in the microscope would move no more than half a millimetre in 100 years. In other words, 2000 times slower than continental drift.

The SuperSTEM 2, or Scanning Transmission Electron Microscope, works by scanning a beam that has been focussed down to the size of an atom, across a sample, providing chemical information on the sample at the same time. Although scanning transmission electron microscopy has been used as a technique for some years, detailed imaging of atoms was previously impossible due to defects that all lenses suffer from. SuperSTEM 2 is a great advance on traditional techniques as it has an inbuilt computer-controlled system corrects these defects, much in the same way that glasses correct the defects in people's eyes.

SuperSTEM also has applications in medicine and is being used to aid understanding of diseases such as the inherited disease haemochromatosis, where the liver becomes overloaded with iron. The tiny particles that hold iron within the body are being examined as their structure will shed light on how iron is transported, stored and released in the body and why they become toxic to the body when there is too much of it.

The University of Liverpool's Dr Andrew Bleloch, Technical Director of SuperSTEM 2 at the Daresbury Laboratory said: "Our society places huge value on making things smaller, cheaper, faster and more effective. This often requires the creation of new materials, new ways of making materials and the understanding of the atoms within them. Progression in nanotechnology makes this all possible, but with this comes the responsibility of ensuring that these products are safe to use. The behaviour of atoms can change, depending on the size of the particle they are in. SuperSTEM 2 means that researchers can now study how these atoms behave in their 'native' form and how they might perform as components of different products that come into contact with human beings. An example of this would be how face creams or sun lotions work and how our bodies will react with the atoms found within them."

The SuperSTEM 2 is now being applied to a whole raft of projects, including medical research to achieve a deeper understanding of liver disease. It is also being used in the future development of mountain bike tyres and the next generation of computer chips in the quest to make smaller, yet more powerful, computers and mobile phones.

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Article adapted by Medical News Today from original press release.
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Source: Wendy Taylor
Science and Technology Facilities Council