Scientists Reveal A New Target To Fight Bad Cholesterol

Main Category: Cholesterol
Article Date: 11 Feb 2008 - 1:00 PDT

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Scientists have uncovered a new region in the genome that is responsible for the body's ability to regulate bad cholesterol which is linked to heart attack and stroke. Their findings are published in the Lancet.

The researchers found three genetic variations in the same region on chromosome 1 which were all linked to levels of LDL-cholesterol in the blood.

Teams from the Medical Research Council Epidemiology Unit, the Wellcome Trust Sanger Institute, Cambridge University and GlaxoSmithKline, studied data from large numbers of people across Europe. They looked at genome-wide scans of more than eleven thousand people to find out which genes affect LDL-cholesterol levels.

Dr Manjinder Sandhu, from the MRC Epidemiology Unit and Department of Public Health & Primary Care, Cambridge University, and lead researcher for the study said: "While therapies exist to lower cholesterol levels in people whose levels are too high, much is still unknown about the mechanisms that underlie cholesterol regulation and why some people seem to produce more than others."

He went on: "Although what you eat is definitely a factor in your cholesterol levels and some bad cholesterol is dietary in origin, the majority of LDL-cholesterol is produced by the body. Performing a genome-wide study, looking for areas which are associated with cholesterol levels helps us to find out why some people produce more than others."

"We might be able to use this information to identify which people are particularly at risk of developing cholesterol problems. We can also look at the function of the genes involved and find out in what way someone may be having problems regulating bad cholesterol levels. This could help us to design more specific and appropriate treatments," says Dr Sandhu.

Professor Nick Wareham, director of the MRC Epidemiology Unit explained the scale of the study: "This represents a mammoth statistical effort by teams in publicly-funded research establishments, the charitable sector and industry.

"The collaborative spirit in which the research was carried out and the access to the data and expertise of academic and industry scientists has made this a particularly exciting project, generating solid data that provides novel insights into the regulation of cholesterol."

Professor Paul Matthews, Vice-president of Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline, emphasised the importance of a new partnership in genetics research between GSK and the MRC to find causes for common diseases: "GSK is looking for innovation to bring better medicines to patients. Breakthroughs when dealing with big clinical problems can only come out of open, highly collaborative science like this. GSK is committed to this partnership which it is hoped will yield further results."

Notes:

- LDL-cholesterol concentrations: a genome-wide association study
Manjinder S Sandhu, Dawn M Waterworth, Sally L Debenham, et al.
Lancet 2008; 371: 483-91

- The research was funded by the Medical Research Council, Wellcome Trust, British Heart Foundation (BHF), European Commission, and GlaxoSmithKline.

- GlaxoSmithKline - one of the world's leading research-based pharmaceutical and healthcare companies - is committed to improving the quality of human life by enabling people to do more, feel better and live longer. For more information and the company's product development pipeline, visit GSK at http://www.gsk.com.

- The Wellcome Trust is the largest charity in the UK. It funds innovative biomedical research, in the UK and internationally, spending around £650 million each year to support the brightest scientists with the best ideas. The Wellcome Trust supports public debate about biomedical research and its impact on health and wellbeing. http://www.wellcome.ac.uk

- The British Heart Foundation (BHF) is the nation's heart charity, dedicated to saving lives through pioneering research, patient care, campaigning for change and by providing vital information. But we urgently need help. We rely on donations of time and money to continue our life-saving work. Because together we can beat heart disease. For more information go to http://www.bhf.org.uk

Medical Research Council