Beyond The Abstract - Uroplakin III-Delta4 Messenger RNA As A Promising Marker To Identify Nonulcerative Interstitial Cystitis

Main Category: Urology / Nephrology
Also Included In: Genetics;  Biology / Biochemistry
Article Date: 24 Feb 2008 - 0:00 PDT

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BERKELEY, CA (UroToday.com) - Uroplakin III-delta 4, a splice variant of UP III, was isolated by my Japanese colleagues, Dr. T Yoshiki and others, although its protein structure and function still remains unclear. In this study, the up-regulation of UP III-delta 4 gene was specifically found in non-ulcerative type interstitial cystitis (IC). At the time of this first report, specific antibodies against this variant form had not been available. We therefore could not confirm up-regulation of UP III-delta 4 in non-ulcerative type IC at protein level. We are now trying to confirm the findings at protein level. If we could establish new diagnostic system for UP III-delta 4 protein, new knowledge about IC including relationship between ulcerative type and non-ulcerative type IC would be provided

Written by

Yoshiyuki Kakehi, MD, PhD, as part of Beyond the Abstract on UroToday.com. This initiative offers a method of publishing for the professional urology community. Authors are given an opportunity to expand on the circumstances, limitations etc... of their research by referencing the published abstract.

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