Interest In Study

Most interested in study. Husband is on Excelon 9.5 mg patch and it has helped a little. However, he still is having short-term memory lapses. If there were anyway that I could help this man, I would. Wondered if there would be adverse effects with the patch? Also, wondered I could get him into a study. Thank you.

Read the news article that this opinion was posted about:
Insulin Via Nasal Spray May Slow Alzheimer's

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alzheimer

posted by Ruth Dingeman on 14 Sept 2011 at 1:38 pm

Please advise how can I get my husband in on the insulin research?

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Not recruiting

posted by Jenny Hutchings on 15 Sept 2011 at 6:07 am

I'm afraid the trial is "ongoing but not recruiting" http://clinicaltrials.gov/show/NCT00438568

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Other options - Metformin that helps cells use insulin better could help

posted by Mark Garrabrant on 16 Sept 2011 at 8:48 am

Have seen some research that suggests Metformin that helps cells use insulin better could help. Metformin is generic and cheap. 30 day RX's are available for $4.00 or less per month

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We can not wait, we want to try - nasal spray insulin for AD

posted by Irina Spector on 26 Sept 2011 at 11:55 am

The result of nasal spray insulin for AD is evidently positive and without dangerous side effect. The official trial will take many years.My husband has AD. We desperately want to find helpful treatment.Give us permission to try nasal spray insulin without any guarantee for positive effect and without payment from any insurance.Many AD patients would like to try. And patients will report to company by mail or Email their own evaluation of treatment every month or quarter.Give AD patients this oppotunity!

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Significant Advance

posted by James Ross on 10 Nov 2011 at 6:02 pm

This appears to be a significant advance in the reduction of symptoms. The long term benefits for patients with early onset remains unknown. However, The short term benefits may also inhibit the progression. Either way, This is a significant advancement in our treatment of Alheimer's Disease.

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Short term gain and longterm pain?

posted by sten46 on 15 Dec 2011 at 11:02 am

Alzheimer's Disease (AD) has in new research been attributed to insulin resistance (IR) of the brain. Higher insulin levels will of course in improve "fuel penetration" and slow or even improve AD as described, but of course only short term. Higher insulin will also cause blood sugar drops followed by added hunger and possible weight gain. Spray inhalation and injection are much the same, both increasing blood levels. Long-term side effects of the proposed spray inhalation would be standard effects of "hyperinsulinemia" ,that has been shown to cause health deterioration and in well controlled studies also been shown to correlate with cancer growth and aggressivity of cancers, etc.. (See Jan Hammersten - prostate cancer)

If the carer isn't too concerned of the long time prognosis the spray could be a good thing.
But instead one could change the diet to "low carb high fat" - LCHF - as it would reduce elevated insulin quickly and long term possibly restore the primarily defunct insulin sensitivity, not only for the brain. I have tried LCHF for BPH and I must say that it has improved me years in just a few weeks, in this aspect only of course. The LCHF is close to a Stone Age (Paeolitic) diet; then plenty of carbohydrates were only available a short time every year, if at all.

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Short term gain and longterm pain?

posted by sten46 on 15 Dec 2011 at 3:35 pm

Alzheimer's Disease (AD) has in new research been attributed to insulin resistance (IR) of the brain. Higher insulin levels will of course in improve "fuel penetration" and slow or even improve AD as described, but of course only short term. Higher insulin will also cause blood sugar drops followed by added hunger and possible weight gain. Spray inhalation and injection are much the same, both increasing blood levels. Long-term side effects of the proposed spray inhalation would be standard effects of "hyperinsulinemia" ,that has been shown to cause health deterioration and in well controlled studies also been shown to correlate with cancer growth and aggressivity of cancers, etc.. (See Jan Hammersten - prostate cancer)

If the carer isn't too concerned of the long time prognosis the spray could be a good thing.
But instead one could change the diet to "low carb high fat" - LCHF - as it would reduce elevated insulin quickly and long term possibly restore the primarily defunct insulin sensitivity, not only for the brain. I have tried LCHF for BPH and I must say that it has improved me years in just a few weeks, in this aspect only of course. The LCHF is close to a Stone Age (Paeolitic) diet; then plenty of carbohydrates were only available a short time every year, if at all.

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any corelation to diabetes

posted by theresa on 09 Feb 2012 at 5:08 pm

have had elderly relative with alzheimers and one with aphasia which is a form of dementia. After reading the comments about insulin, I would like to know if someone with diabetes or hypoglycemia in are more likel to develop alzheimers?

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