Regulatory T Cells In Patients Treated With Adacolumn Granulocytapheresis

Main Category: Genetics
Also Included In: Genetics
Article Date: 04 May 2008 - 1:00 PDT

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An increased expression of FoxP3 mRNA and a higher frequency of CD25+ regulatory cells were found in all patients who responded to cytapheresis but this was not found in a nonresponder patient. Variations in TGF-beta (mRNA) did not parallel those of FoxP3 mRNA. It is suggested that the quantification of FoxP3 in CD4+ T cells of treated patients may be used as a valuable index in these conditions.

This study, performed by a team led by Dr. Emilio Cuadrado, is described in a research article to be published on March 14, 2008, in the World Journal of Gastroenterology.

This is a very interesting study. The authors showed that granulocytes and monocytes by adsorption (GMA) induces an increase in Treg and stimulates an anti-inflammatory response in IBD patients.

In this study, it is reported that an increased expression of Fox P3 mRNA was found in all five patients who responded to cytapheresis with remission of clinical symptoms, mucosal inflammation, and cutaneous lesions, and an increased frequency of circulating Treg was found in four patients; these changes were not observed in the patient with ulcerative colitis (UC) who did not respond to GMA. Variations in TGF- (mRNA) did not parallel those of FoxP3 mRNA.

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Reference: Cuadrado E, Alonso M, de Juan MD, Echaniz P, Arenas JI. Regulatory T cells in patients with inflammatory bowel diseases treated with adacolumn granulocytapheresis. World J Gastroenterol 2008; 14(10): 1521-1527 http://www.wjgnet.com/1007-9327/14/1521.asp

Correspondence to: Dr Emilio Cuadrado, Sección de Inmunología, Hospital Donostia, Pº doctor Begiristain s/n 20014, San Sebastian, Spain.

About World Journal of Gastroenterology

World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection for providing a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2003-2000 IF: 3.318, 2.532, 1.445 and 0.993. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. The WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.

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Source: Jing Zhu
World Journal of Gastroenterology

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