Does 1q31.1-32.1 Harbor A Tumor Suppressor Gene Related To Chinese SCC Patients?

Main Category: Colorectal Cancer
Also Included In: Genetics
Article Date: 01 May 2008 - 5:00 PDT

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The LOH analysis on sporadic carcinoma by means of microsatellite markers has become an effective way to find allelic deletion regions and then to find candidate tumor suppressor genes. In a previous study, it was found that D1S413 (1q31.1-32.1, 9.8cM) exhibited higher LOH frequencies, which indicated that the region might harbor the putative tumor suppressor gene(s). However, the allelic deletion region contained so many genes that it was inconvenient to continue the gene screening and functional study. Therefore, further LOH scanning with high-density microsatellite markers in the region was found to be necessary to narrow the research scope and select fewer candidate genes in the finite regions for functional research.

This study, performed by Dr. Chong-Zhi Zhou and his colleagues, is described in a research article to be published on March 14, 2008, in the World Journal of Gastroenterology.

They analyzed refined LOH mapping of 1q31.1-32.1 and found a minimal region of frequent deletion located within a 2-cM genomic segment at D1S413-D1S2622 on 1q31.3-32.1.

Then by searching in the databases, they presumed that CSRP1 might be the candidate colorectal carcinoma-related gene in this region.

In the view of the authors, the genetic changes in colorectal carcinogenesis are not fully understood. However, LOH analysis is an effective method to find informative loci and subsequently identify candidate tumor suppressor genes.

This study found the critical and precise deleted region on 1q31.1-32.1 and provided significant data to help reveal the mechanisms of colorectal carcinogenesis.

Further research should carry out microarray-based high-throughput gene screening and should include functional research for finding the potential tumor suppressor gene.

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Reference: Zhou CZ, Qiu GQ, Fan JW, Wang XL, Tang HM, Huang L, Sun YH, Peng ZH.
Refined mapping of loss of heterzygosity on 1q31.1-32.1 in sporadic colorectal carcinoma.
World J Gastroenterol 2008; 14(10): 1582 http://www.wjgnet.com/1007-9327/14/1582.asp

Correspondence to: Dr. Zhi-Hai Peng, Department of General Surgery, Shanghai Jiaotong University affiliated First People's Hospital, 85 Wujin Road, Shanghai 200080, China.

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World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection for providing a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2003-2000 IF: 3.318, 2.532, 1.445 and 0.993. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. The WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.

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Source: Jing Zhu
World Journal of Gastroenterology

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