Absence Of Viable Carcinoma In Biopsies Performed Greater Than 1-Year Following Radiofrequency Ablation Of Renal Cortical Tumors

Main Category: Urology / Nephrology
Also Included In: Cancer / Oncology
Article Date: 19 Jun 2008 - 0:00 PDT

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ORLANDO, FL (UroToday.com) - Stern and colleagues report on their experience with tissue biopsy more than 1 year after radiofrequency ablation (RFA) of small renal masses. The study included 19 patients with 20 renal masses (17 pre-treatment proven RCC and 3 oncocytomas) that had previously undergone RFA ablation, were stable in size on follow-up, and showed no evidence of enhancement on imaging. These lesions were percutaneously biopsied at a mean follow-up of 26.9 (13.1 - 58.0) months. Pathological evaluation, using H&E staining, revealed coagulation necrosis, hyalinization, immune cell infiltration, residual ghost cells, and no evidence of residual viable tumor.

Previous studies reported preserved tumor architecture for several months following RFA; therefore, current findings with longer-term follow up are significant. The biology of tumor-kill following RFA ablation is not clear-cut and deserves research efforts.

Presented by Joshua Stern, MD, Jay D. Raman, MD, and Jeffrey Cadeddu, MD, at the Annual Meeting of the American Urological Association (AUA) - May 17 - 22, 2008. Orange County Convention Center - Orlando, Florida, USA.

Reported by UroToday.com Contributing Editor Alexander Kutikov, MD

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