Age Related Increase Of Reactive Oxygen Species In Neat Semen In Healthy Fertile Men

Main Category: Urology / Nephrology
Also Included In: Fertility
Article Date: 26 Jun 2008 - 2:00 PDT

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ORLANDO, FL (UroToday.com) - The objective of this study was to analyze the relationship between male age and seminal reactive oxygen species (ROS) levels in men presenting for voluntary sterilization. Comparison of seminal parameters, leukocyte levels and ROS levels in neat semen among fertile men over 40 years, fertile men under 40 years and control (infertile) patients.

The authors found that seminal ROS levels are significantly higher in healthy fertile men older than 40 years. They hypothesize that because high ROS levels have been associated in the pathogenesis of male infertility that delayed fatherhood may reduce the chances of pregnancy as men become progressively less fertile.

Editoral comment: This is another study which is designed to assess the impact of ROS on fertility. The control groups were infertile males. The ROS in this group was not stratified by age. Additionally, it would have been helpful to assess the interval since last conception as this may provide additional information regarding the fertility status of the patients with increased ROS. The fertility data for this group with proven fertility should be correlated with the ROS status as well as age.

Presented by Marcello Cocuzza, MD, et al., at the Annual Meeting of the American Urological Association (AUA) - May 17 - 22, 2008. Orange County Convention Center - Orlando, Florida, USA.

Reported by UroToday.com Contributing Editor Harris M. Nagler, MD

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