Does Hydronephrosis On Preoperative Axial CT Imaging Predict Worse Outcomes For Nephrouretectomy Patients For Upper-Tract Urothelial Carcinoma?

Main Category: Urology / Nephrology
Also Included In: Cancer / Oncology;  MRI / PET / Ultrasound;  Radiology / Nuclear Medicine
Article Date: 26 Jun 2008 - 6:00 PDT

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ORLANDO, FL (UroToday.com) - Dr. Casey Ng and colleagues evaluated whether hydronephrosis in the setting of upper tract TCC was a marker for more aggressive disease and worse outcomes.

106 patients from two institutions were included in the study. 37% had hydronephrosis. Not surprisingly patients with hydronephrosis were more likely to have TCC in the ureter vs. the renal pelvis (p=0.01). Presence of hydronephrosis correlated with higher stage disease (p=0.03), lymph node involvement (p=0.05), and non-organ confined disease (p=0.01). Multivariate analysis revealed hydronephrosis to be an independent predictor of future metastatic disease and cancer-specific mortality.

These data are consistent with previous reports that demonstrate ominous impact of hydronephrosis on prognosis in lower tract TCC.

Presented by Casey K. Ng, MD, et al., at the Annual Meeting of the American Urological Association (AUA) - May 17 - 22, 2008. Orange County Convention Center - Orlando, Florida, USA.

Reported by UroToday.com Contributing Editor Alexander Kutikov, MD

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