Next Generation Data Analysis For Next Generation Sequencing Data

Main Category: Genetics
Also Included In: IT / Internet / E-mail;  Biology / Biochemistry
Article Date: 03 Jul 2008 - 4:00 PDT

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Genomatix Software, a company with an outstanding track record in the analysis of genomic data generated by high throughput technologies, has announced availability of the Genomatix Genome Analyzer. The Genomatix Genome Analyzer (GGA) is the first integrated hardware / software solution for in-depth analysis of data generated by next generation sequencing (NGS) devices as provided by Illumina, Roche (454), Applied Biosystems (SOLiD) and Helicos.

Terabytes of locally installed data integrated with Genomatix powerful analysis technology facilitate easy extraction of relevant biological knowledge from mammalian ChIP-seq and transcriptome studies.

A typical analysis of a ChIP-seq experiment with 10 million reads takes only 2 hours. Results contain all important information: clustered and classified enriched regions, transcription factor (TF) over-representation and TF associations. In addition, genome-wide correlations with genomic features as well as meta-analysis with genome-wide chromatin modification, methylation state, expression levels or any data derived by other NGS experiments can be added with a few mouse clicks. Identification of phylogenetically conserved functional elements add another dimension of analytic power.

Transcriptome studies result in normalized and quantified expression values and allow for immediate identification of new transcriptional units and splice variants, all integrated and visualized in today's most complete genome annotation ElDorado, which is built into the GGA.

The GGA is driven by an easy-to-use, integrated browser based interface. Alternatively all database structures, scripts and tools are open and accessible to the bio-informatics specialist for re-arrangement or integration of own procedures.

"I am really excited about the power and possibilities arriving with all this new technology!", says Klaus May, Chief Business Officer of Genomatix. "All this flood of data arriving from NGS now reinforce our developments over the last decade. We have a unique knowledge base which together with our leading technology lifts biological understanding to the next level. Further proof comes from a multitude of projects and a series of scientific publications to be out shortly. The GGA empowers the researcher beyond comparison. All you need, in one box on your desk." he concludes.

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Source: Klaus May
Genomatix Software GmbH

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