Targeted Therapies To Lead New Wave Of Breast Cancer Treatments
Main Category: Breast CancerAlso Included In: Cancer / Oncology
Article Date: 03 Jul 2008 - 4:00 PDT
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Rising public awareness about breast cancer and the treatments available has greatly improved revenues in the overall breast cancer therapeutics market. To thrive in this highly competitive market, drug developers must offer drugs that improve survival rates and the quality of life.
New analysis from Frost & Sullivan, U.S. Breast Cancer Therapeutics Markets, finds that the targeted therapies segment of the market earned revenues of $1.34 billion in 2007 and estimates this to reach $3.34 billion in 2013.
The fastest growing segment of the U.S. population belongs to the aging segment, where the highest rates of breast cancer occur. The breast cancer market will remain a visibly important area of oncology. Companies are putting their research dollars into developing targeted breast cancer therapies that offer patients not only increased efficacy, but reduced side effects as well.
These innovative, targeted therapies have shown the greatest promise in the market and many are touting them as the future of breast cancer treatment. Combinations of these highly specific therapies with existing cytotoxic and hormonal therapies are rapidly becoming the standard of oncology care.
"Future research into treatment strategies will focus on drugs with clear therapeutic potential, as well as minimal side-effect profiles," says Frost & Sullivan Research Analyst Misty Hughes. "Specialized therapies such as monoclonal antibodies, angiogenesis inhibitors, and vaccines could make a significant impact through targeted mechanisms of action and minimized toxicities."
As the cost to develop new drugs increases, so does the degree of difficulty for smaller companies to develop products that make it through the approval process. These smaller companies must often seek and obtain licensing partnerships with larger corporations in order to defray costs associated with bringing new drugs to the market.
While smaller companies receive the required funds and personnel resources for developing new compounds, large enterprises expand their portfolio of potential new products, helping them proactively manage their pipelines.
"In order to attract larger companies, smaller companies must conduct well-designed pre-clinical tests that culminate in favorable results from phase I trials," notes Hughes. "The higher the potential of the investigative compound for treating more than one cancer is, the greater the likelihood of partnerships."
U.S. Breast Cancer Therapeutics Markets is part of the Pharmaceutical & Clinical Diagnostics Growth Partnership Service program, which also includes research in the following markets: European market for breast cancer therapeutics, world breast cancer therapeutics market, U.S. multiple myeloma market, and the U.S. colorectal cancer market. All research services included in subscriptions provide detailed market opportunities and industry trends evaluated following extensive interviews with market participants. Interviews with the press are available.
Frost & Sullivan, the Growth Partnership Company, partners with clients to accelerate their growth. The company's TEAM Research, Growth Consulting and Growth Team Membership empower clients to create a growth-focused culture that generates, evaluates and implements effective growth strategies. Frost & Sullivan employs over 45 years of experience in partnering with Global 1000 companies, emerging businesses and the investment community from more than 30 offices on six continents.
Frost & Sullivan
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Targeted Agents The Short Term Future Of Cancer Therapeutics
posted by Gregory D. Pawelski on 3 Jul 2008 at 9:10 pmI think that functional, cell-based tests would be vastly more informative on virtually all drugs than marker-based tests, including multi-gene tests.
Functional profiling assays can include anti-vascular drugs, such as Avastin, Sutent, Nexavar, Tarceva, Iressa, Tykerb, both as single agents and in combination with each other and with traditional cytotoxic agents and hormonal therapies.
It can provide more valuable information today than will be provided with marker and genomic based assays 10 years from now. It can simultaneously test for direct anti-tumor activity and for antivascular activity against the microvascular present within the three dimensional tumor cell clusters.
There has been unique cell culture research a new bio-marker assay for microvascular viability to identify potential responders to Avastin, Nexavar, Sutent, and other anti-angiogenic drugs by targeting not the cells themselves, but rather VEFG secreted by tumor cells, and to assess previously unanticipated direct and potentiating anti-angiogenic effects of targeted therapy drugs such as Tarceva and Iressa.
Prior to this development, it was thought that the lack of an intact tumor micro-vasculature would prevent in vitro drug studies in disaggregated tissues. However, it was discovered that endothelial cells are present in tumor microclusters and it appears that drug effect upon these cells can be assessed in this microvascular assay.
It is the only assay which involves direct visualization of the cancer cells at endpoint, allowing for accurate assessment of drug activity, discriminating tumor from non-tumor cells, and providing a permanent archival record, which improves quality, serves as control, and assesses dose response in vitro.
Photomicrographs in the assay can show that some clones of tumor cells don't accumulate the drug. These cells won't get killed by it. The assay measures the net effect of everything which goes on (Functional Tumor Cell Profiling). Are the cells ultimately killed, or aren't they?
I too believe that the short term future of cancer therapeutics is combinations of "targeted" agents, not only for breast cancer treatments, but for all solid cancers.
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