Possible Link Found Between X-rays And Prostate Cancer

Main Category: Prostate / Prostate Cancer
Also Included In: Radiology / Nuclear Medicine;  GastroIntestinal / Gastroenterology;  Bones / Orthopedics
Article Date: 17 Jul 2008 - 1:00 PDT

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Researchers at The University of Nottingham have shown an association between certain past diagnostic radiation procedures and an increased risk of young-onset prostate cancer - a rare form of prostate cancer which affects about 10 per cent of all men diagnosed with the disease.

The study, the first of its kind to report the relationship between low dose ionising radiation from diagnostic procedures and the risk of prostate cancer, was funded by the Prostate Cancer Research Foundation (PCRF) and is part of the UK Genetic Prostate Cancer Study (UKGPCS). The results of the study have been published online in the British Journal of Cancer.

The study showed that men who had a hip or pelvic X-ray or barium enema 10 years previously were two and a half times more likely to develop prostate cancer than the general population. And the link appeared to be stronger in men who had a family history of the disease.

The research was led by Professor Kenneth Muir, from the Division of Epidemiology and Public Health at The University of Nottingham, in association with Dr Rosalind Eeles at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust.

Professor Muir said: "Although these results show some increase in the risk of developing prostate cancer in men who had previously had certain radiological medical tests we want to reassure men that the absolute risks are small and there is no proof that the radiological tests actually caused any of the cancers."

Four hundred and thirty one men, diagnosed with young onset prostate cancer - men diagnosed with the disease before the age of 60 - took part in the study.

The exposure to radiation was part of normal medical procedures which were performed 5, 10 or 20 years before diagnosis. Procedures included hip and leg X-rays, for example taken after an accident, and barium meals and enemas which are used to diagnose problems with the digestive system.

At this stage the evidence linking diagnostic radiation procedures and prostate cancer is still weak. This research suggests that further investigation into this link should be undertaken.

X-ray procedures used for diagnostic purposes deliver very small amounts of radiation per procedure. Their use is minimised in current medical practice. For most people X-rays do not increase the risk of developing cancer.

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The University of Nottingham is ranked in the UK's Top 10 and the World's Top 70 universities by the Shanghai Jiao Tong (SJTU) and Times Higher (THE) World University Rankings.

It provides innovative and top quality teaching, undertakes world-changing research, and attracts talented staff and students from 150 nations. Described by The Times as Britain's "only truly global university", it has invested continuously in award-winning campuses in the United Kingdom, China and Malaysia.

Twice since 2003 its research and teaching academics have won Nobel Prizes. The University has won the Queen's Award for Enterprise in both 2006 (International Trade) and 2007 (Innovation - School of Pharmacy).

Its students are much in demand from 'blue-chip' employers. Winners of Students in Free Enterprise for four years in succession, and current holder of UK Graduate of the Year, they are accomplished artists, scientists, engineers, entrepreneurs, innovators and fundraisers. Nottingham graduates consistently excel in business, the media, the arts and sport. Undergraduate and postgraduate degree completion rates are amongst the highest in the United Kingdom.

Source: Professor Kenneth Muir
University of Nottingham

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