Propofol Low-Dose Lessens Haemorrhagic Shock-Induced Organ Damage In Conscious Rats - Clinical And Experimental Pharmacology And Physiology

Main Category: Neurology / Neuroscience
Also Included In: Clinical Trials / Drug Trials;  Blood / Hematology
Article Date: 23 Jul 2008 - 1:00 PDT

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This study investigates the effects of treatment with differing levels of propofol after haemorrhagic shock (HS) on conscious rats.

HS is secondary to major blood loss and frequently precedes multiple organ failure, often resulting in death. A low dose of propofol (1mg/kg/hour) after HS suppressed increased levels of inflammatory cytokines and protected against HS-induced organ damages.

The high dose (10mg/kg/hour) however, increased inflammatory mediators and led to more severe pathological damage in the liver, lung and small intestine. Propofol is an anti-inflammatory agent commonly used for general anesthesia and sedation in intensive care patients.

As HS increases the sedative effects of propofol, patients in HS should only receive 10-20% of the propofol dose administered to a healthy patient.

"Low-dose propofol ameliorates haemorrhagic shock-induced organ damage in conscious rats"
Chung-Jen LEE, Yi-Maun SUBEQ, Ru-Ping LEE, Wen-Tien WU and Bang-Gee HSU
DOI 10.1111/j.1440-1681.2007.04859.x
Clinical and Experimental Pharmacology and Physiology Volume 35 Issue 7, Pages 766 - 774
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Clinical and Experimental Pharmacology and Physiology

Clinical and Experimental Pharmacology and Physiology provides a medium for the rapid publication of original research papers, short communications, rapid communications and theoretical articles (hypotheses) on the results of clinical and experimental work in pharmacology and physiology. Invited review articles are published occasionally.

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