Continuous Sivelestat Sodium Hydrate Infusion Averts Lipopolysaccharide-Induced Intestinal Paralysis And Hypotension In Conscious Guinea-Pigs

Main Category: Respiratory / Asthma
Also Included In: Clinical Trials / Drug Trials
Article Date: 23 Jul 2008 - 1:00 PDT

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This study examined the effects of continuous administration of sivelestat sodium hydrate (sivelestat) on guinea pigs induced with intestinal paralysis and hypotension.

Findings suggest that sivelestat - a neutrophil elastase (NE) inhibitor- can effectively reduce intestinal dysfunction and attenuate hypotension.

NE is a protease released in response to inflammation and is believed to trigger acute respiratory distress syndrome (ARDS) and ARDS-related lung injury.

Sivelestat is a specific NE inhibitor used to treat acute lung injury in Japan. It is still undergoing clinical trials around the world.

"Continuous infusion of sivelestat sodium hydrate prevents lipopolysaccharide-induced intestinal paralysis and hypotension in conscious guinea-pigs"
Shunsuke Hara, Kayo Nemoto, Norifumi Ninomiya, Minoru Kubota, Masamune Kuno, Yasuhiro Yamamoto
Clinical and Experimental Pharmacology and Physiology Volume 35 Issue 7, Pages 841 - 845
10.1111/j.1440-1681.2008.04921.x
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Clinical and Experimental Pharmacology and Physiology

Clinical and Experimental Pharmacology and Physiology provides a medium for the rapid publication of original research papers, short communications, rapid communications and theoretical articles (hypotheses) on the results of clinical and experimental work in pharmacology and physiology. Invited review articles are published occasionally.

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