Long Term Follow-up Demonstrates The Correlation Between D90 And Outcomes For I-125 Seed Implant Monotherapy For Localised Prostate Cancer

Main Category: Radiology / Nuclear Medicine
Also Included In: Prostate / Prostate Cancer;  Urology / Nephrology;  Cancer / Oncology
Article Date: 22 Sep 2008 - 3:00 PDT

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Prostate cancer is one of the most common cancers in men. One treatment option for those with early disease is prostate brachytherapy, where small radioactive sources are implanted directly into the gland.

Brachytherapy treatments are technically challenging. To ensure high quality treatments are consistently delivered, CT scans are used to demonstrate the radioactive source positions and calculate the actual dose delivered to the prostate (post implant dosimetry). This study compared post implant dosimetry results with the long term outcomes of a group of 688 men who had undergone prostate brachytherapy between March 1995 and September 2004.

Men had CT scans taken 6-8 weeks following implantation with post implant dosimetry calculated for each patient. Patients were then followed up with PSA (Prostate specific Antigen) blood levels to assess whether or not prostate cancer was in remission.

Comparing 10 year PSA control we found that patients who received a higher dose of radiation to the prostate had better results (78% vs. 88% PSA control rates). This study provides strong clinical evidence for the importance of delivering high doses of radiation to the prostate when using brachytherapy.

Henry Ann M. et al. St James's Institute of Oncology, Leeds, United Kingdom

About ESTRO 27

ESTRO 27 (September 14th to 18th, 2008) offered an outstanding scientific programme combining lectures from eminent invited speakers, proffered papers and poster discussions, teaching lectures on a wide range of topics including clinical issues, brachytherapy, radiobiology, physics and technology as well as debates on controversial topics and clinical case discussions, a special poster reception, poster discussion sessions and electronic poster viewing.

ESTRO 27 hosted the largest European exhibition in Radiotherapy with participation from all the leading manufacturers.

ESTRO 27

ESTRO (European Society for Therapeutic Radiology and Oncology)

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