Oxybutynin Chloride Topical Gel For Overactive Bladder: Effects Of Showering, Sunscreen And Person-to-Person Transference

Main Category: Urology / Nephrology
Article Date: 27 Oct 2008 - 3:00 PDT

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PHILADELPHIA, PA, USA (UroToday.com) - Three open-label randomized studies were conducted in healthy men and women to investigate the effects of showering, sunscreen, and person-to-person transfer of oxybutynin chloride topical gel (OTG).

OTG is a clear, fast-drying, once-daily, ethanol-based formulation that delivers approximately 4 mg/day of oxybutynin transdermally and is associated with a low incidence of skin reactions. In the showering study, subjects received OTG for 35 days; on days 14, 21, 28, and 35, subjects showered not at all for 1, 2, or 6 hours after dosing. In the sunscreen study, subjects received OTG alone, OTG 30 minutes after sunscreen application, or OTG 30 minutes before sunscreen application. In the transference study, a single dose of OTG was administered to 1 partner each in a group of matched couples; after 1 hour, each couple engaged in 15 minutes of abdomen-to-abdomen contact with movement. The treated partners were randomly assigned to wear a T-shirt or to have a bare abdomen; the untreated partners all had bare abdomens. Blood was drawn for determination of oxybutynin plasma concentrations and pharmacokinetic parameters.

These studies indicate that using OTG one hour before showering or 30 minutes before or after applying sunscreen is acceptable. Although transference of oxybutynin can occur, the Cmax is approximately one fourth of that with direct treatment; transference is almost completely prevented if the treated individual wears a thin shirt. Transference at other application sites (shoulder and thigh) has not been studied.

Presented by D. K. Newman, K. E. Caramelli, S. Stanworth, W. Volinn, and G. Hoel, at the 39th Annual Conference of the Society of Urologic Nurses and Associates - October 3 - 6, 2008 - Philadelphia, PA, USA

Reported by UroToday.com Contributing Editor Diane K. Newman, MSN, CRNP, FAAN, BCIA-PMDB

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