Rapid Screening System May Lead To Prevention Or Delay Of Alzheimer's Disease

Main Category: Alzheimer's / Dementia
Also Included In: Biology / Biochemistry;  Preventive Medicine
Article Date: 18 Dec 2008 - 0:00 PDT

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Australian scientists at CSIRO (Commonwealth Scientific and Industrial Research Organisation), have developed a new system to screen for compounds that can inhibit one of the processes that takes place during the progression of Alzheimer's disease. In a paper published in the November issue of the Journal of Alzheimer's Disease, folate is shown to be beneficial in the screening system.

Lead author, CSIRO's Dr Ian Macreadie says folate is already well known to have a protective effect against Alzheimer's disease, which is believed to be caused by the loss of neurons in the brain due to a process whereby toxic multimers of a small protein called Aβ are formed.

"However, a team of scientists working within CSIRO's Preventative Health Flagship has discovered a rapid screening system to identify inhibitors of this process. Compounds that inhibit the formation of the toxic multimers may lead to the prevention or delay of the disease," Dr Macreadie says.

"Although many other research groups and drug companies around the world are trying to find compounds that act in the same way, the advance by the Flagship team involves using live yeast with the Aβ protein fused to a green fluorescent protein that comes from jellyfish.

"The significance of this development is that the yeast trial we developed could lead to the discovery of new agents which may prove useful in preventing or delaying the onset of Alzheimer's disease."

Currently Alzheimer's disease is an incurable illness and the fourth leading cause of death in people aged 65 years and over.

Although folate is abundant in foods like leafy green vegetables, legumes and liver, CSIRO studies have shown that many Australians do not consume enough folate to benefit from its ability to prevent cell damage. Folate levels can, however, be readily restored by dietary folate supplementation.

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CSIRO initiated the National Research Flagships to provide science-based solutions in response to Australia's major research challenges and opportunities. The nine Flagships form multidisciplinary teams with industry and the research community to deliver impact and benefits for Australia.

The article is "Validation of Folate in a Convenient Yeast Assay Suited for Identification of Inhibitors of Alzheimer's Amyloid-β Aggregation" by Ian Macreadie, Mehrnoush Lotfi-Miri, Sameera Mohotti, Deborah Shapira, Louise Bennett, Jose Varghese.. It is published in the Journal of Alzheimer's Disease 15:3 (November 2008).

Source: Astrid Engelen
IOS Press

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