Targeted Therapies Are Replacing The Oncology Superdrugs, According To New Cutting Edge Information Report
Main Category: Cancer / OncologyAlso Included In: Pharma Industry / Biotech Industry
Article Date: 30 Jan 2009 - 4:00 PDT
The oncology drug treatment landscape is in the midst of change, according to Cutting Edge Information's latest market forecast report "Oncology Roadmap: Brand Spending Benchmarks and Market Forecast to 2013" (http://www.cuttingedgeinfo.com/oncology). The idea of the "superdrug" is quickly giving way to increasingly targeted therapies. In fact, by 2013, while Gleevec and Avastin will still reap blockbuster sales, most oncology therapies will only focus on very specific patient populations.
The American Society of Clinical Oncology's recent recommendation reflects this trend. The society made headlines in January by advising oncologists not to prescribe leading oncology drugs Vectibix and Erbitux to certain colon cancer patients. Research reveals that patients with KRAS gene mutations will not respond to anti-EGFR therapy.
With more than 1 in 3 patients exhibiting KRAS mutations, the future looks a little less bright for these two brands. The Wall Street Journal estimates that not prescribing Erbitux as a first-line treatment for metastatic colon cancer will decrease Bristol-Myers Squibb's and Eli Lilly's top-line annual sales by $600 million.
"While upsetting for these two companies -- not to mention Amgen with Vectibix -- every oncology drug maker will have to adjust its R&D strategies to meet payer demands," says Jeremy Spivey, lead author of Cutting Edge Information's report. "With payers increasingly demanding customized oncology therapies that target only those patients who will see the greatest benefit, pharma companies must find cost-efficient ways to provide them."
"Oncology Roadmap: Brand Spending Benchmarks and Market Forecast to 2013" (http://www.cuttingedgeinfo.com/oncology) delivers high-level analysis of the future state of the oncology market. The report also includes primary data on brand spending benchmarks for market access, advertising and promotions, decision support and medical affairs.
Brand Profiles detail products' competitive and strategic positioning, market opportunities and patent and litigation data. Profiles include sales forecasts, clinical trial information and competitor analysis, leading to an overall impression of where the drug will be in the next several years.
Company Profiles show breakdowns for the top seven companies with established cancer franchises or exciting development pipelines. These profiles contain company rankings and key products, as well as an analysis of each oncology portfolio's strengths, growth areas, and competitor threats.
To download a complimentary brochure of the report, go to http://www.cuttingedgeinfo.com/oncology.
Cutting Edge Information
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http://www.medicalnewstoday.com/releases/137331.php.
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The Problem With Mutation Or Amplification Studies
posted by Gregory D. Pawelski on 30 Jan 2009 at 10:06 pmThe situation with Erbitux/Vectibix is that all the EGFR mutation or amplification studies can tell us is whether or not the cells are potentially susceptible to this mechanism of attack. They don’t tell you if Erbitux/Vectibix is worse or better than some other drug which may target this.
The cell is a system, an integrated, interacting network of genes, proteins and other cellular constituents that produce functions. You need to analyze the systems’ response to drug treatments, not just one target or pathway.
No genetic profile can discriminate differing levels of anti-tumor activity occurring among different targeted therapy drugs. Nor can it identify situations in which it is advantageous to combine a targeted drug with other types of conventional cancer drugs.
EGFR-targeted drugs are poorly-predicted by measuring the ostansible target, but can be well-predicted by measuring the effect of the drug on the function of live cells. You still need to measure the net effect of all processes, not just the individual molecular targets.
I would not want to be denied treatment with EGFR antibody therapy because of KRAS gene testing. KRAS gene testing for EGFR is not a clear predictor of a lack of benefit from EGFR antagonist antibodies in colon cancer.
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