William C. Reeves New Investigator Award Won By UC Davis Malaria Researcher Win Surachetpong

Main Category: Tropical Diseases
Also Included In: Biology / Biochemistry
Article Date: 11 Feb 2009 - 3:00 PDT

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Malaria researcher Win Surachetpong, a doctoral candidate at the University of California, Davis, is the 2009 winner of the William C. Reeves New Investigator Award, given to the best scientific paper presented at the annual Mosquito and Vector Control Association of California (MVCAC) meeting.

Surachetpong received $1000 and a plaque at the 77th annual MVCAC meeting, held in Burlingame. His scientific paper focused on regulating the development of malaria parasites.

"Win is a very talented, dedicated student and I have been extremely fortunate to have him in my lab," said his major professor and malaria researcher Shirley Luckhart, an associate professor of medical microbiology and immunology at the UC Davis School of Medicine, and a faculty member of the Graduate Groups of Biochemistry and Molecular Biology; Microbiology; Immunology; and the Graduate Program in Entomology.

"His work," she said, "has been the foundation of the development of a completely new area of work for us that will probably keep us busy for years to come."

The award memorializes a renowned entomologist and professor at UC Berkeley who was widely regarded as the world's foremost authority on the spread and control of mosquito-borne diseases. Reeves (1916-2004) was a frequent visitor to the UC Davis campus.

Surachetpong said that malaria "remains an enormous public health burden, especially in developing countries." Malaria, caused by the parasite Plasmodium and transmitted by infected anopheline mosquitoes, strikes some 350 to 500 million people a year, killing more than a million, according to the Centers for Disease Control and Prevention.

"New strategies including integrated vector management in combination with current conventional malaria control efforts such as drug treatment and bednet usage could synergistically reduce malaria transmission," Surachetpong said.

"However, our current knowledge of vector-host-parasite interactions is limited," he noted. "For example, how mosquito innate immune responses control malaria parasite development and how blood-derived factors modulate mosquito biology remain interesting topics."

"In this study, we reveal the role of MEK-ERK (mitogen-activated protein kinase/extracellular signal-regulated kinase) signaling in regulation of malaria parasite development by an ingested blood-derived, mammalian cytokine in the mosquito host."

The results, the researchers said, "provide new insights into the host-parasite-vector relationship that could be utilized as a foundation for new strategies to reduce malaria transmission."

Surachetpong titled his paper "MAPK/ERK Signaling Regulates the TGF-Betal Dependent Mosquito Response to Plasmodium falciparum." TGF-beta is a transforming growth factor beta synthesized by skeletal cells and found in most species.

A native of Thailand, Surachetpong joined the Luckhart lab and the Immunology Graduate Group in 2005. He is seeking his doctorate in immunology, with a designated emphasis in vectorborne diseases. His doctoral thesis is "MAPK Signaling Pathways Regulate Anti-Malarial Response in Anopheles Mosquitoes."

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Last year Surachetpong was awarded a prestigious Bill and Melinda Gates Foundation health travel award to present his research at a Keystone Symposia conference in Bangkok, Thailand. The meeting focused on the pathogenesis and control of emerging infections and drug-resistant organisms. Surachetpong received his doctorate of veterinary science degree at Chulalongkorn University, Bangkok in 2000, ranking first in his class, and his master of science degree in pathobiology in 2005 from the University of Arizona, with high honors.

Source: Kathy Keatley Garvey
University of California - Davis

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