Hydroxyapatite-Coating Of Cellulose Sponges Attracts Bone Marrow-Derived Stem Cells In Rat Subcutaneous Tissue

Main Category: Stem Cell Research
Also Included In: Dermatology;  Biology / Biochemistry
Article Date: 11 Mar 2009 - 7:00 PDT

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The presence of bone marrow-derived stem cells was investigated in a rat subcutaneous wound healing model using cellulose to induce granulation tissue formation.

Cellulose coated with hydroxyapatite resembling the natural mineral (calcium phosphate) composition of bone attracted circulating hematopoietic and mesenchymal progenitor cells more efficiently than uncoated cellulose.

As in bone marrow, where calcium sensing receptors regulate the retaining of hematopoietic stem cells, these same receptors seem to be involved in the homing of hematopoietic stem cells to the hydroxyapatite-coated cellulose.

This cell-guiding property of hydroxyapatite-coated cellulose might be useful in clinical situations involving impaired wound repair.

Journal of the Royal Society Interface

Journal of the Royal Society Interface is the Society's cross-disciplinary publication promoting research at the interface between the physical and life sciences. It offers rapidity, visibility and high-quality peer review and is ranked fifth in JCR's multidisciplinary category. The journal also incorporates Interface Focus , a peer-reviewed, themed supplement, each issue of which concentrates on a specific cross-disciplinary subject.

Journal of the Royal Society Interface

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