Rapidly Mutating Yeast Causing More Infections

Main Category: Infectious Diseases / Bacteria / Viruses
Article Date: 02 Apr 2009 - 7:00 PDT

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During the recent years yeasts have been causing more and more infections in humans. One of them can mutate surprisingly quickly by reorganizing its chromosomes. This enables this yeast to tolerate higher doses of anti-fungal medicine. This is shown by new research findings from the Lund University in Sweden.

A yeast named Candida glabrata commonly occurs in humans, usually on our skin. It does little harm there. But if it enters the blood system, it can be directly life threatening to people with poor immune defense, such as cancer and AIDS patients.

"It can actually eat you up from the inside," says Jure Piskur, professor at the Department of Cell and Organism Biology at the Lund University.

Jure Piškur, together with a team of research colleagues, has studied the underlying reasons that this yeast can cause more and more infections in humans. The research team has discovered that Candida glabrata can mutate surprisingly rapidly. Instead of mutations occurring in individual genes, this yeast can mutate by reorganizing their chromosomes and make extra copies of large chromosome pieces.

The consequence of this is that Candida glabrata is becoming more and more resistant to fungicidal medicine. The present research report shows that a certain mini-chromosome can enable the yeast fungus to survive even if it is treated with nearly ten times the normal dose of the fungicide fluconazole.

"Our research now aims to identify the weak points in Candida glabrata so that we can develop effective medicine," says Jure Piskur.

Candida glabrata has become the second most common yeast pathogen in humans. It primarily causes irritation, in the genitals, for instance. Jure Piskur stresses that people whose immune defense is normal run very little risk of being affected by the life-threatening form of fungal infection in the blood system.

The most common type of fungus in humans is called Candida albicans and causes commonly occurring infections in women's genitals. This yeast fungus is relatively easy to treat with fungicides. But more and more often after the treatment Candida albicans is replaced with the more resistant Candida glabrata.

Vetenskapsradet (The Swedish Research Council)
http://www.vr.se

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