Use Of Adipose Stem Cells And Polylactide Discs For Tissue Engineering Of The Temporomandibular Joint Disc

Main Category: Stem Cell Research
Article Date: 22 May 2009 - 5:00 PDT

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There is currently no suitable replacement for the irreversibly damaged temporomandibular joint (TMJ) discs after discectomy. In this study, we designed a TMJ disc shaped scaffold of biodegradable polylactide and combined it with adipose stem cells (ASCs).

The expression of the extracellular matrix components, typical for the normal TMJ disc, was induced in the ASC-seeded PLA discs in chondrogenic medium.

The expression was close to similar to conventional pellet cultures but still remained from that measured in the positive control tissue. The combination of ASCs and PLA discs has potential for the development of a tissue-engineered TMJ disc replacement.

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Journal of the Royal Society Interface

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Journal of the Royal Society Interface. "Use Of Adipose Stem Cells And Polylactide Discs For Tissue Engineering Of The Temporomandibular Joint Disc." Medical News Today. MediLexicon, Intl., 22 May. 2009. Web.
14 Feb. 2012. <http://www.medicalnewstoday.com/releases/151127.php>

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Journal of the Royal Society Interface. (2009, May 22). "Use Of Adipose Stem Cells And Polylactide Discs For Tissue Engineering Of The Temporomandibular Joint Disc." Medical News Today. Retrieved from
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Stem Cell Research

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