Breakthrough Could Lead To New Antimicrobial Drugs

Main Category: Infectious Diseases / Bacteria / Viruses
Article Date: 12 Jun 2009 - 3:00 PDT

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Scientists have discovered exactly how some bacteria act to protect themselves when they are threatened or under attack.

After 25 years of painstaking studies - led by Professor Ian Booth at the University of Aberdeen and Dr Tarmo Roosild at Nevada Cancer Institute in Las Vegas - scientists have figured out the mechanics of 'channels' in bacteria which stay shut if all is normal and are triggered to open if they need to mount a defence.

The breakthrough finding published in the journal Structure paves the way for the development of new methods for tackling E.coli, salmonella and brucella infections; as well as the bacteria Pseudomonas, which often colonise the lungs of cystic fibrosis patients and also cause infection in those whose immune systems are compromised.

Professor Booth collaborated with Nevada Cancer Institute and the Salk Institute in San Diego, California on the research which received funding by the Wellcome Trust.

The research focused on E.coli but the protective channel system is common to many pathogens that cause infection and disease.

Professor Booth said: "I started work to understand this system in 1984 so it is tremendously exciting to have made this breakthrough in understanding the molecular workings of these protective channels that are found in several pathogens, many of which are increasingly resistant to traditional antibiotics.

"Our next challenge is to design chemicals that fool the bacterium into locking the channel open all the time, which will then impair its growth, or we could lock it shut so it can't protect itself."

Dr Roosild added: "Discovery of new drugs through the structural analysis of proteins that underlie diseases, including cancer, and are potentially molecular targets for therapeutic intervention, is the primary focus of our research.

"The hope is that these particular studies will eventually lead to the development of new medicines that will cure people with deep seated bacterial infections such as those in intensive care."

Additional scientists contributing to this breakthrough include Samantha Castronovo at Nevada Cancer Institute, Samantha Miller, Chan Li, Tim Rasmussen, Wendy Bartlett and Banuri Gunasekera at the University of Aberdeen, and Senyon Choe at the Salk Institute.

About the University of Aberdeen

The University of Aberdeen is a centre of excellence for life sciences. Translational research is a particular strength for the University as its health campus is based on one of the largest teaching hospital sites in Europe. Lately the University has made major strategic investments to consolidate its position as one of the world's key centres for R&D in life sciences and medical research.

About Nevada Cancer Institute

Nevada Cancer Institute (NVCI) is the official cancer institute for the State of Nevada. A nonprofit organization, NVCI is committed to reducing the burden of cancer by pursuing the development of a comprehensive cancer research institute, as defined by the National Cancer Institute. Through the knowledge and expertise of the finest scientists, clinicians, educators and caregivers, the Institute provides hope to communities in Nevada, the southwest and beyond through research, education, early detection, prevention and high quality patient care. NVCI is striving for a future without cancer that is achieved through initiated and collaborative research in basic, clinical and population science. For more information, please visit http://www.nevadacancerinstitute.org or call (702) 822-LIFE.

Source
Wellcome Trust

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