Acceleron To Present ACE-031 Preclinical Study Results As Treatment For Loss Of Muscle Mass And Function
"Treatment with a Form of Soluble Activin Receptor Type IIB Ameliorates the Effects of Estrogen Deficiency on Lean, Adipose and Bone Tissues"
Date: Wednesday, June 10, 2009
Session Time: 11:15 am
Room: 154AB, Walter E. Washington Convention Center
"Treatment with a Soluble Activin Receptor Type IIB Prevents Androgen-Deprivation-Induced Effects on Muscle, Bone and Fat"
Date: Friday, June 12, 2009
Session Time: 11:15 am
Room: 144C, Walter E. Washington Convention Center
"Age-Related Lean Tissue Loss and Adipose Tissue Gain Is Attenuated by Treatment with a Form of Soluble Activin Receptor Type IIB"
Date: Saturday, June 13, 2009
Session Time: 1:15 pm
Room: 143C, Walter E. Washington Convention Center
"These three presentations continue the ongoing stream of exciting preclinical data demonstrating the therapeutic effects of Acceleron's ACE-031 program across a wide array of disease models," said Jasbir Seehra, Ph.D., Chief Scientific Officer at Acceleron. "There is enormous clinical potential of this molecule to treat patients suffering from a range of conditions such as neuromuscular diseases, cancer cachexia, metabolic diseases and age-related muscle loss. We are completing a Phase 1 study in healthy volunteers and look forward to announcing these results later this year."
Muscle is increasingly recognized as central to many biological processes and plays a major role in human health. The loss of muscle mass and strength is ultimately directly related to the cause of death in neuromuscular diseases such as muscular dystrophy and amyotrophic lateral sclerosis. Severe muscle loss in cancer leads to serious complications and a poor prognosis. Muscle loss is a natural consequence of aging, similar to bone loss, resulting in decreased muscle strength (frailty), reduced mobility and an increased risk of a fall and broken bones. In metabolic diseases, an imbalance of diet, energy utilization and skeletal muscle leads to poor metabolic function. By increasing muscle mass there is a corresponding decrease in fat mass and improvements in metabolic function.
ACE-031, a soluble molecule based on the activin receptor type IIB (ActRIIB), is a biologic therapeutic that inhibits signaling through the ActRIIB receptor. By blocking signaling though ActRIIB, ACE-031 increases muscle mass and strength. In numerous and varied animal models of disease, ACE-031 significantly increased muscle mass and muscle strength. ACE-031 has shown encouraging preclinical results in animal models of age-related muscle loss, neuromuscular disease, cancer treatment-related muscle loss and metabolic diseases. ACE-031 is currently being studied in a Phase 1 clinical trial.
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