Breast Cancer Gene Issues Surface

Main Category: Breast Cancer
Also Included In: Genetics
Article Date: 18 Dec 2009 - 0:00 PDT

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The Center for Modeling Optimal Outcomes, LLC, a New Jersey based think tank focused on the application of neuroscience in business, inadvertently discovered a scientifically verifiable model for assessing homeostasis (balance) between substances in the body.

The Center's model for assessing homeostasis is grounded in the laws of physics and chemistry which dictate all matter is comprised of positive, negative and neutral electrical charges (known in physics as neutrons and in chemistry as transitional elements). Part of the model is supported by the fact that the body is comprised of matter and "powered" by a minute amount of electricity. In turn, like all matter in the universe, substances in the body are also positive, negative or neutral.

The Center has already announced the portion of its model pertaining to cellular absorption on November 18, 2009 in a press release relative to a possible cause of one form of autism. In order to provide evidence of the universal applicability of the model, the Life Sciences group of The Center applied it to existing scientific literature regarding breast cancer to determine if causal paths could be identified.

According to William McFaul, The Center's founder, "As a result of applying the model of homeostasis to existing breast cancer research studies, highly probable causal links surfaced. GRB-7 and HER-3 emerged as genes (proteins) that, when 'over-expressed' are capable of disrupting the homeostatic relationship (balance) between the genes (proteins) HER-1 and HER-2. Another possible disruption associated with another iteration of breast cancer is the one between the genes (proteins) BRCA-1 and BRCA-2. Although the source of the second disruption is a bit less clear in the scientific literature, the gene (protein) COBRA-1 appears to be a likely candidate."

Craig Angelini, The Center's biology advisor commented, "While the model for homeostasis and its associated concepts will transform most of the processes used in biological research, caution must be exercised not to make assumptions without thorough laboratory research using established protocols. The Center's findings will enable the research community to use a new lens to identify possible and highly probable causal paths and variables that can lead to illnesses and diseases. As a think tank, we have focused our efforts on developing models and tools that will enable the scientific community to find the answers."

McFaul added, "Since The Center's model for homeostasis is universal for all substances in the body, the Life Sciences group has also been able to identify several other highly probable variables that must occur simultaneously to create a 'perfect storm' of disruptions that can result in breast cancer. Likely candidates for such disruptions (imbalances) that were identified will be shared with the cancer research community. Not being in the domain of research, we fully understand our limitations and final determinations of causes of diseases must be left to the experts."

The additional variables identified include but are not limited to those involving signaling dynamics for mitochondria, possible disruptions in processes for apoptosis (cell death), imbalances in surface proteins responsible for apoptosis, and the disruption of homeostatic relationships of other tumor markers currently used as individual biomarkers (e.g. alpha-fetoprotein AFP). Because linkages between corollary relationships of the various substances associated with the aforementioned processes are not obvious in current literature without considering homeostasis, adequate explanations will require detailed discussions with members of the research community.

Included in discoveries made by The Center, the application of the rate of cellular absorption also appears to be a major factor in breast cancer as well as most other disease entities. This transformational model for cellular absorption expands the maxim of toxicology postulated by Paracelsus (1493 - 1541) from "the dose determines the poison" to include "the rate of cellular absorption determines the level of toxicity." The model for cellular absorption is explained on The Center's web site in the tab for Life Sciences.

Angelini explained, "Identifying causal paths for any disease state has been elusive because so many disruptions must occur at the same time. Traditional cause and effect modeling has not been able to produce the desired results."

Linda Oliver-Perrier, the spokesperson for The Center's Life Sciences group explained, "Our intention was not to become involved with scientific research methodologies. While finalizing a business model utilizing neuroscience in business for overcoming change inertia, one of our team members identified a novel relationship between brain chemicals. The implications of this discovery forced us to set aside the promotion of our completed model for creating a culture of change acceptability. A separate Life Sciences group was then formed to address the model of corollary relationships of substances in the body. The outcome of these investigations into process beyond neurobiology led to the formulation of the irrefutable model for assessing homeostatic relationships between substances in the body."

Source: The Center for Modeling Optimal Outcomes LLC

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