Discovery Of Cells Critical To Childhood Leukemia
The team, led by Dr Matthew McCormack and Dr David Curtis of the Rotary Bone Marrow Research Laboratories and the University's Department of Medicine at The Royal Melbourne Hospital, made the discovery whilst studying mice prone to developing this leukaemia.
The results have been published online today by the prestigious international journal Science.
The team found that with irradiation treatment in animal models, over 99 per cent of cells in the thymus were killed, but these stem cell-like cells persisted and rapidly recovered. This suggests that these cells may survive therapy and be responsible for relapsed disease following treatment.
Currently, children with T-ALL are given extended therapy over two to three years in an attempt to stop a relapse. More targeted therapy on the thymus cells could reduce the length and toxicity of treatment and prevent relapse.
Dr McCormack, a leading international expert on childhood leukaemia, said: "The cellular origins of this leukaemia are not well understood. Our discovery that these cells are similar to normal stem cells explains why they are capable of surviving for long periods. It also explains why they are remarkably resistant to treatment."
Approximately 50 new cases of T-ALL are diagnosed every year in Australia, two thirds of these in children or adolescents. Adults also contract T-ALL, and the majority succumb to resistant or relapsed disease.
Dr Curtis, a Clinical Haematologist and head of the Leukaemia Research Program at The Royal Melbourne Hospital, said: "The identification of these cells provides an important target for the development and testing of new treatments for patients with T cell Acute Lymphoblastic Leukaemia."
The team will now focus on novel treatments capable of killing these cells, which may lead to clinical trials within the next five years.
The research also involved Walter & Eliza Hall Institute of Medical Research and Leeds Institute of Molecular Medicine, UK.
The research was supported by the National Health and Medical Research Council of Australia, Cancer Council Victoria, Leukaemia Foundation of Australia and the Fight Cancer Foundation (BMDI).
Source: Rebecca Scott
University of Melbourne
There are no references listed for this article.
Please use one of the following formats to cite this article in your essay, paper or report:
Scott, Rebecca. "Discovery Of Cells Critical To Childhood Leukemia." Medical News Today. MediLexicon, Intl., 22 Jan. 2010. Web.
25 Jun. 2017. <http://www.medicalnewstoday.com/releases/176853.php>
Scott, R. (2010, January 22). "Discovery Of Cells Critical To Childhood Leukemia." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
Contact our news editors
For any corrections of factual information, or to contact our editorial team, please see our contact page.
Copyright Medical News Today: Excluding email/sharing services explicitly offered on this website, material published on Medical News Today may not be reproduced, or distributed without the prior written permission of Medilexicon International Ltd. Please contact us for further details.