A Potential Chemotherapeutic Drug To Treat Hepatocellular Carcinoma

Main Category: Cancer / Oncology
Also Included In: GastroIntestinal / Gastroenterology;  Nutrition / Diet
Article Date: 02 Aug 2010 - 0:00 PDT

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Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, particularly in China. However, HCC remains one of the more difficult cancers to treat. It is important to screen for new anti-cancer drugs. A number of dietary compounds possess anti-cancer properties. These dietary compounds may modify the activity of specific targets that control cell proliferation and apoptosis. Galangin could inhibit the methoxyresorufin O-demethylase activity of CYP1A2, CYP1A1 and P-form phenolsulfotransferase. Galangin induced apoptosis in several cancer cell lines and arrested the cell cycle, modulated the expression of cycline/cdk, and decreased Bcl-2. It was suggested that galangin may be a potential anti-tumor agent. However, the mechanism by which galangin exerts its anti-tumor activity is unknown.

A research article published in the World Journal of Gastroenterology addresses this issue. This is the first study to report that galangin mediates apoptosis through a mitochondrial pathway.

Their data demonstrated that:

1. galangin induces HCC cell apoptosis by triggering Bax translocation to the mitochondria;
2. galangin-treated HCC cells causes the release of AIF and cytochrome c into the cytosol from the mitochondria; and
3. overexpression of Bcl-2 attenuated galangin-induced HepG2 cells apoptosis, while down-regulated Bcl-2 expression enhanced galangin to induce cell apoptosis.

Understanding the mechanism by which galangin induces apoptosis may lead to its use as an anti-cancer treatment of HCC. This study may represent a future potential chemotherapeutic drug in the treatment of HCC with galangin.

Reference:
Zhang HT, Luo H, Wu J, Lan LB, Fan DH, Zhu KD, Chen XY, Wen M, Liu HM. Galangin induces apoptosis of hepatocellular carcinoma cells via the mitochondrial pathway. World J Gastroenterol 2010; 16(27): 3377-3384

Source:
Ye-Ru Wang
World Journal of Gastroenterology

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