Long-Term Survival in Lung Transplantation

Main Category: Lung Cancer
Article Date: 02 Apr 2005 - 7:00 PDT


Based on a study of 752 French patients who underwent either lung or heart-lung transplantation, investigators revealed a close relationship between graft ischemic time and long-term survival after single or double lung transplantation. (Graft ischemic time was defined as the interval between the application of the aortic cross clamp during donor organ removal and the reperfusion (restoration of blood flow) in the graft of the recipient.)

According to the authors, a cutoff time of 330 minutes was found to best discriminate between long-term survivors and nonsurvivors.

The median time for the entire group in the transplant study was 240 minutes. Results were unaffected by the organ preservation fluid used.

The investigators believe that expected graft ischemic time should be incorporated into the decision-making process at the time of graft acceptance.

The investigators note that the effect of graft ischemic time on the relative risk of death seemed to peak in the first year after transplantation, and to wear off quickly thereafter.

During the study period, from January 1987 to December 1998, patient survival at the seven French transplantation centers which were involved in the study ran 84.2 percent at day 30, 63.3 percent at 1 year, 45.9 percent at 3 years, and 38.1 percent at 5 years.

The research study appears in the first issue for April 2005 of the American Thoracic Society's peer-reviewed American Journal of Respiratory and Critical Care Medicine.

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For the complete text of these articles, please see the American Thoracic Society Online Web Site at http://www.atsjournals.org. For either contact information or to request a complimentary journalist subscription to ATS journals online, or if you would like to add your name to the Society's twice monthly journal news e-mail list, contact Cathy Carlomago at 212-315-6442, or by e-mail at ccarlomagno@thoracic.org .

Contact: Cathy Carlomagno
ccarlomagno@thoracic.org
212-315-6442
American Thoracic Society
http://www.thoracic.org

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