Exercise Increases Soluble Vascular Endothelial Growth Factor Receptor-1 (sFlt-1) in Circulation of Healthy Volunteers

Main Category: Sports Medicine / Fitness
Article Date: 04 Apr 2005 - 16:00 PDT

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Physical inactivity a well-established risk factor for cancer, but the molecular mechanisms are unclear.

The researchers found that exercise-induced circulating sFlt-1 was associated with a decrease in unbound circulating VEGF.

The function of sFlt-01 is to bind to VEGF to block its activity as one the most potent stimulators of blood vessel growth under physiological and pathological conditions.

Formation of new blood vessels is a key pathogenic step for development of cancer and atherosclerosis.

Amelia Purser Bailey, Megan Shparago, Jian-Wei Gu. Physiology & Biophysics, University of Mississippi Medical Center. Physiology 348.4. Featured topic session #770: "Muscle as an endocrine organ."

The 35th Congress of the International Union of Physiological Sciences is in San Diego, March 31 - April 5, 2005. The Congress (http://www.iups2005.org) is organized by the six member societies of the U.S. National Committee of the IUPS, the American Physiological Society, the Society for Neuroscience, the Microcirculatory Society, the Society of General Physiologists, the Biomedical Engineering Society, and the Society for Integrative and Comparative Biology, under the auspices of the U.S. National Academy of Sciences.

The IUPS conference, held every four years, runs concurrently this year with Experimental Biology 2005 at the San Diego Convention Center.

Abstracts for all presentations may be accessed through a complete searchable online program at faseb.org/meetings/eb2005/call/default.htm covering both IUPS and Experimental Biology 2005, which is being held concurrently.

The American Physiological Society (APS), which is hosting IUPS, was founded in 1887 to foster basic and applied science, much of it relating to human health. The Bethesda, MD-based Society has more than 10,000 members and publishes nearly 4,000 articles every year in its 14 peer-reviewed journals. In May, APS received the Presidential Award for Excellence in Science, Mathematics and Engineering Mentoring (PAESMEM).

Contact: Mayer Resnick
mresnick@the-aps.org
301-332-4402 (cell)
619-525-6228 (Telephone)
301-634-7209 (office, outside IUPS dates)
The American Physiological Society
http://www.the-aps.org

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