Scientists develop new treatment for hereditary breast cancer

Main Category: Breast Cancer
Article Date: 13 Apr 2005 - 11:00 PDT

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Researchers at the University of Sheffield, funded by Yorkshire Cancer Research, have discovered a new way of treating and preventing hereditary breast cancer. The latest finding describes how the use of a chemical inhibitor can specifically kill tumour cells, which have a defect in the gene causing hereditary breast cancer. This new treatment targets only the tumour cells and is not likely to affect other healthy cells in the body. This discovery could also lead to a vaccine to prevent hereditary breast cancer.

Breast cancer accounts for a third of cancers among women, of which one in ten will inherit the disease. In most women, the BRCA1 and BRCA2 genes prevent breast tumours from forming, but some women have inherited mutations in these genes, giving them about an eighty per cent risk of developing breast cancer.

Funded by Yorkshire Cancer Research, Dr Helen Bryant, of the Division of Genomic Medicine at the University of Sheffield commented: "Normal cells replicate by dividing DNA into two strands and copying each strand. Before replication, damage in the DNA is usually repaired using a protein called PARP. If PARP is absent or inhibited then the cells use a second mechanism called recombination to fix the damage and continue to replicate. Cells with mutated BRCA genes can't undergo recombination and therefore rely completely on PARP to fix the damage. "

"The new treatment uses a chemical that prevents PARP from repairing the DNA, making recombination essential. The breast cancer tumour cannot perform recombination and is therefore unable to replicate and create new cells. The tumour is then unable to grow and eventually dies.

"The beauty of this system is that only the tumour cells lack BRCA genes and thus only they completely rely on PARP. The other cells in the body are likely to be unaffected by the treatment and continue to use recombination to repair any mistakes that occur."

Dr Thomas Helleday, the head of the Sheffield research group says, "As this treatment is non toxic, it could also be used as a vaccine for women carrying the gene responsible for inherited breast cancer, preventing tumours from developing." He adds: "Both the treatment and the vaccine are new concepts in cancer therapy. They could lead to revolutionary new treatments for women with hereditary breast cancer within the next few years."

http://www.shef.ac.uk

SOURCE: http://www.alphagalileo.org

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