Weight Gain Induced By High-Fat Diet Increases Active-Period Sleep And Sleep Fragmentation
Using radio-telemetry, the authors measured 24-hour sleep and wake states after rats consumed a high fat diet for 8 weeks. Compared to rats that consumed a standard laboratory chow, the rats on the high-fat diet slept more but sleep was fragmented. The increased sleep time of the rats on the high-fat diet occurred mainly during the normally active phase of the day, resembling excessive daytime sleepiness observed in obese humans.
According to lead author, Catherine Kotz, "Studies in humans indicate a relationship between sleep quality and obesity. Our previous work in animals shows a link between good quality sleep, resistance to weight gain and increased sensitivity to orexin, a brain chemical important in stabilizing sleep and wake states. The current studies show that after high-fat diet-induced weight gain in rats, sleep quality is poor and orexin sensitivity is decreased. These findings suggest that poor sleep associated with weight gain due to a high-fat diet may be a consequence of reduced orexin sensitivity".
These studies highlight the impact of weight gain on sleep quality and a potential brain mechanism underlying these diet and weight-gain induced changes in sleep behavior.
Lead Author: Catherine M. Kotz, University of Minnesota and Veterans Affairs Medical Center, Minneapolis, MN, USA
Co-Authors: C.J. Billington and V. Mavanji, University of Minnesota and Veterans Affairs Medical Center, Minneapolis, MN, USA
Society for the Study of Ingestive Behavior
Source: EurekAlert!, the online, global news service operated by AAAS, the science society
Please use one of the following formats to cite this article in your essay, paper or report:
Society for the Study of Ingestive Behavior. "Weight Gain Induced By High-Fat Diet Increases Active-Period Sleep And Sleep Fragmentation." Medical News Today. MediLexicon, Intl., 11 Jul. 2012. Web.
27 Apr. 2017. <http://www.medicalnewstoday.com/releases/247645.php>
Society for the Study of Ingestive Behavior. (2012, July 11). "Weight Gain Induced By High-Fat Diet Increases Active-Period Sleep And Sleep Fragmentation." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
Contact our news editors
For any corrections of factual information, or to contact our editorial team, please see our contact page.
Copyright Medical News Today: Excluding email/sharing services explicitly offered on this website, material published on Medical News Today may not be reproduced, or distributed without the prior written permission of Medilexicon International Ltd. Please contact us for further details.