HIV Drug Shows Efficacy In Treating Mouse Models Of HER2+ Breast Cancer
Breast cancer is one of the most common causes of cancer deaths in the U.S. with approximately 39,520 women succumbing to the disease in 2011. HER2-postive breast cancer is known to be more aggressive and less responsive to treatments compared to other types of breast cancer. Nelfinavir has been shown to inhibit the growth of some types of cancers and has been used in clinical trials as either a chemotherapeutic agent or a radiosensitizer for cancer therapy. However, its effect on HER2-positive breast cancer is unknown.
In order to determine the effects of Nelfinavir on HER2-positive breast cancer, Joong Sup Shim, Ph.D., of the Department of Pharmacology and Molecular Sciences at Johns Hopkins School of Medicine and colleagues screened the Johns Hopkins Drug Library and identified a number of inhibitors of breast cancer cells, a subset of which was then used to pharmacologically profile seven genotypically individual breast cancer cell lines. After identifying Nelfinavir as a selective inhibitor of HER2-positive cells, the researchers determined the antitumor activity of the inhibitor in mouse models of human breast cancer.
The researchers found that Nelfinavir inhibited the growth of HER2-positive tumors in mice. They also found that the concentrations of Nelfinavir needed to inhibit HER2-positive cancer cells in vitro are consistent with dosage regimens used for HIV patients. "With a relatively low toxicity profile and much available information on its drug-drug interactions and on pharmacokinetics, Nelfinavir is ready for clinical testing in HER2 breast cancer patients," the authors write, adding that this discovery has, "important implications in the development of Nelfinavir and its analogs as new anticancer agents."
For a PDF Version of the Study:http://www.oxfordjournals.org/our_journals/jnci/press_releases/shimdjs396.pdf
JNCI - Journal of the National Cancer Institute
Please use one of the following formats to cite this article in your essay, paper or report:
JNCI, . "HIV Drug Shows Efficacy In Treating Mouse Models Of HER2+ Breast Cancer." Medical News Today. MediLexicon, Intl., 5 Oct. 2012. Web.
26 Aug. 2016. <http://www.medicalnewstoday.com/releases/251075.php>
JNCI, . (2012, October 5). "HIV Drug Shows Efficacy In Treating Mouse Models Of HER2+ Breast Cancer." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
Contact our news editors
For any corrections of factual information, or to contact our editorial team, please see our contact page.
Copyright Medical News Today: Excluding email/sharing services explicitly offered on this website, material published on Medical News Today may not be reproduced, or distributed without the prior written permission of Medilexicon International Ltd. Please contact us for further details.