The study was published online in The American Journal of Human Genetics.
The research team, led by Cynthia Morton, PhD, BWH director of the Center for Uterine Fibroids and senior study author, analyzed genetic data from over 7,000 white women. The researchers detected genetic variants that are significantly associated with uterine fibroid status in a span of three genes including FASN which encodes a protein called FAS (fatty acid synthase).
Moreover, additional studies revealed that FAS protein expression was three times higher in uterine fibroid samples compared to normal myometrial tissue (muscle tissue that forms the uterine wall). Over-expression of FAS protein is found in various types of tumors and is thought to be important for tumor cell survival.
"Our discovery foretells a path to personalized medicine for women who have a genetic basis for development of uterine fibroids," said Morton. "Identification of genetic risk factors may provide valuable insight into medical management."
Study samples used were from various cohort studies, such as the Finding Genes for Fibroids study and the Women's Genome Health Study at BWH.
Uterine fibroids may lead to abnormal vaginal bleeding, infertility, pelvic pain and pregnancy complications. Uterine fibroids are found in more than 75 percent of women of reproductive age.
This research was supported by the National Institute of Child Health & Human Development (HD046226 and HD060530); National Institutes of Health (CA047988, HL043851, HL080467, HL099355, AA07535, AA07728, AA13320, AA13321, AA14041, AA11998, AA17688, DA012854 and DA019951); Australian National Health and Medical Research Council; 5th Framework Programme GenomEUtwin Project; Wellcome Trust; Cooperative Research Centre for Discovery of Genes for Common Human Diseases, Cerylid Biosciences (Melbourne); and National Health and Medical Research Council Fellowship Scheme.
Brigham and Women's Hospital
Source: EurekAlert!, the online, global news service operated by AAAS, the science society
Please use one of the following formats to cite this article in your essay, paper or report:
Brigham and Women's Hospital. "Genetic Risk Discovered For Uterine Fibroids." Medical News Today. MediLexicon, Intl., 8 Oct. 2012. Web.
24 Sep. 2016. <http://www.medicalnewstoday.com/releases/251162.php>
Brigham and Women's Hospital. (2012, October 8). "Genetic Risk Discovered For Uterine Fibroids." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
Contact our news editors
For any corrections of factual information, or to contact our editorial team, please see our contact page.
Copyright Medical News Today: Excluding email/sharing services explicitly offered on this website, material published on Medical News Today may not be reproduced, or distributed without the prior written permission of Medilexicon International Ltd. Please contact us for further details.