- One particular variant within the multidrug resistance 1 (MDR-1) gene in donors was linked to a 69% increased risk for long-term failure of transplanted organs.
- The researchers validated the link in another 3,660 donors, making this the largest study of its kind.
- This variant affects the expression of the protein that the MDR-1 gene encodes, the drug transporter P-glycoprotein.
- No other genetic variants in donors or recipients were linked with organ survival or failure.