Changes In Progenitor Cell Population In Breast May Be Overlooked Factor In Breast Cancer
Changes in the populations of progenitor cells in breast tissue may be a powerful and until now overlooked factor in breast cancer and aging, he said.
According to U.S. breast cancer statistics, over 75 percent of the 200,000 women diagnosed each year are 50 years of age and older.
The popular hypothesis that accumulating gene mutations drive the connection between aging and cancer breaks down on closer study, according to Dr. LaBarge, because the same sets of mutations commonly detected in cancers in older women are often found in cancers in younger women.
By analyzing a wide sample of normal epithelial breast cells taken during noncancer surgeries of women ages 16 to 91 years old, the LaBarge lab discovered that the aging process results in decreased proportions of myoepithelial cells, which are thought to suppress malignant growth, and a simultaneous increase in multipotent progenitors including faulty luminals and few myoeps. These are thought to be the etiological roots of some breast cancers.
The mammary gland is a network of ducts composed of two layers of epithelial cells - the inner milk-producing luminal cells and the outer luminal-supporting myoepithelial (or "myoep") cells. Both types develop from progenitor cells - a small fraction of the cells in the gland that retain the ability to divide.
Progenitor cells are thought to be much more likely to be transformed into tumor cells.
Dr. LaBarge believes that in older women the progenitor cells that normally maintain both types of cells in mammary glands are unable to keep the balance between the lineages. Progenitor cells in older women are less responsive to cues in the breast microenvironment that would promote differentiation into myoepithelial cells in younger women.
The breast microenvironment is a powerful shaper of cell fate, and changes brought on by aging alone, such as altered endocrine profiles, do play a part. But the implication in this new study, said Dr. LaBarge, is that aging leaves women more susceptible to malignant transformation by increasing the potential pool of target cells and decreasing the ability to contain malignancies.
Funding from National Institute on Aging (R00AG033176 and R01AG040081), US Department of Energy, Low Dose Radiation Research Program (DE-AC02-05CH11231), and US Department of Defense, Breast Cancer Research Program (BC060444).
"Aging-related changes make mammary epithelia more vulnerable to cancer: A story of altered stem cells," Monday, Dec. 17, 2012, 12:30 pm, Session: Tumor Microenvironment, presentation: 1674, poster: B1445, Exhibit Halls A-C.
American Society for Cell Biology
Source: EurekAlert!, the online, global news service operated by AAAS, the science society
Please use one of the following formats to cite this article in your essay, paper or report:
American Society for Cell Biology. "Changes In Progenitor Cell Population In Breast May Be Overlooked Factor In Breast Cancer." Medical News Today. MediLexicon, Intl., 24 Dec. 2012. Web.
31 May. 2016. <http://www.medicalnewstoday.com/releases/254243.php>
American Society for Cell Biology. (2012, December 24). "Changes In Progenitor Cell Population In Breast May Be Overlooked Factor In Breast Cancer." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
Contact our news editors
For any corrections of factual information, or to contact our editorial team, please see our contact page.
Copyright Medical News Today: Excluding email/sharing services explicitly offered on this website, material published on Medical News Today may not be reproduced, or distributed without the prior written permission of Medilexicon International Ltd. Please contact us for further details.