Are Bacteria Making You Hungry?
This hypothesis is based in large part on observations of the number of roles bacteria are already known to play in host biology, as well as their relationship to the host system. "Bacteria both recognize and synthesize neuroendocrine hormones," Norris et al. write. "This has led to the hypothesis that microbes within the gut comprise a community that forms a microbial organ interfacing with the mammalian nervous system that innervates the gastrointestinal tract." (That nervous system innervating the GI tract is called the "enteric nervous system." It contains roughly half a billion neurons, compared with 85 billion neurons in the central nervous system.)
"The gut microbiota respond both to both the nutrients consumed by their hosts and to the state of their hosts as signaled by various hormones," write Norris et al. That communication presumably goes both ways: they also generate compounds that are used for signaling within the human system, "including neurotransmitters such as GABA, amino acids such as tyrosine and tryptophan - which can be converted into the mood-determining molecules, dopamine and serotonin" - and much else, says Norris.
Furthermore, it is becoming increasingly clear that gut bacteria may play a role in diseases such as cancer, metabolic syndrome, and thyroid disease, through their influence on host signaling pathways. They may even influence mood disorders, according to recent, pioneering studies, via actions on dopamine and peptides involved in appetite. The gut bacterium, Campilobacter jejuni, has been implicated in the induction of anxiety in mice, says Norris.
But do the gut flora in fact use their abilities to influence choice of food? The investigators propose a variety of experiments that could help answer this question, including epidemiological studies, and "experiments correlating the presence of particular bacterial metabolites with images of the activity of regions of the brain associated with appetite and pleasure."
Formal publication is scheduled for the February 2013 issue of the Journal of Bacteriology.
(V. Norris, F. Molina, and A.T. Gewirtz, 2012. Hypothesis: bacteria control host appetites. J. Bacteriol. Online ahead of print 9 November 2012.)
American Society for Microbiology
Source: EurekAlert!, the online, global news service operated by AAAS, the science society
Please use one of the following formats to cite this article in your essay, paper or report:
American Society for Microbiology. "Are Bacteria Making You Hungry?." Medical News Today. MediLexicon, Intl., 29 Dec. 2012. Web.
26 Jun. 2017. <http://www.medicalnewstoday.com/releases/254318.php>
American Society for Microbiology. (2012, December 29). "Are Bacteria Making You Hungry?." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
Contact our news editors
For any corrections of factual information, or to contact our editorial team, please see our contact page.
Copyright Medical News Today: Excluding email/sharing services explicitly offered on this website, material published on Medical News Today may not be reproduced, or distributed without the prior written permission of Medilexicon International Ltd. Please contact us for further details.