New Rat Model For Muscle Regeneration After Trauma-Related Soft Tissue InjuryMain Category: Rehabilitation / Physical Therapy
Also Included In: Bones / Orthopedics
Article Date: 07 Jan 2013 - 0:00 PST
New Rat Model For Muscle Regeneration After Trauma-Related Soft Tissue Injury
|Patient / Public:|
Penetrating soft tissue injuries that may be caused by bullet wounds or motor vehicle accidents, or exposure to explosive devices in military settings, can cause muscle loss resulting in functional disability and cosmetic deformity. Efforts underway to develop tissue engineering solutions to repair and replace damaged and lost muscle will benefit greatly from the availability of robust animal models to test these innovative therapeutic strategies. A new rat model that simulates traumatic or surgical muscle tissue loss in humans is described in an article in BioResearch Open Access, a bimonthly peer-reviewed open access journal from Mary Ann Liebert, Inc., publishers. The article is available free on the BioResearch Open Access website here.
Xiaowu Wu, MD, Benjamin T. Corona, PhD, Xiaoyu Chen, PhD, and Thomas J. Walters, PhD, United States Army Institute of Surgical Research (Fort Sam Houston, TX), Wake Forest Institute for Regenerative Medicine (Winston-Salem, NC), and University of Texas Health Science Center at San Antonio, provide a detailed description of the methods used to create an animal model with approximately 20% volumetric muscle loss (VML) from the middle third of the tibialis anterior muscle. The authors demonstrate successful repair of the injury using a biological scaffold and present their findings in "A Standardized Rat Model of Volumetric Muscle Loss Injury for the Development of Tissue Engineering Therapies."
Visit our rehabilitation / physical therapy section for the latest news on this subject.
Mary Ann Liebert, Inc./Genetic Engineering News
25 May. 2013. <http://www.medicalnewstoday.com/releases/254579.php>
Please note: If no author information is provided, the source is cited instead.
Contact Our News Editors
For any corrections of factual information, or to contact the editors please use our feedback form.
Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.