ALS, sometimes called Lou Gehrig's disease, is a progressive disease that affects the motor neurons that connect the brain to muscles throughout the body. It is a devastating disease with 90 per cent of patients dying within five years of diagnosis. As many as 30,000 Americans and 2,000 Canadians are living with ALS.
Strong's team is convinced ALS is a disorder of RNA metabolism. RNA is the intermediary or messenger between genes and the protein being made. This new protein appears to play a critical role. "Every time we look at a cell degenerating, this particular protein was deposited abnormally in the cell. It was a common denominator," explains Strong, who is also the Dean of Schulich Medicine & Dentistry. "Working with Dr. Rob Hegele at Robarts, we found there was a genetic mutation in the gene coding for this protein. So it's a huge discovery."
Unlike most proteins which have one key function, this one has two. "One side works with RNA. The other side has the capacity to regenerate or to deal with an injury. We think those are competitive activities so if it's doing one, it's not available to do the other," says Strong. In the case of ALS, Strong believes the protein is disturbed on the RNA side so it's no longer able to respond to cell injury. "We need to understand what causes the switch between the two functions, and then can we modulate it."
The research was funded by the Canadian Institutes of Health Research and the ALS Society of Canada.
University of Western Ontario
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