Rooting Out Recurrent Breast Cancer

Main Category: Breast Cancer
Article Date: 12 Feb 2013 - 0:00 PST



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Due to chemotherapy resistance and a high rate of relapse, triple negative cancers are among the most difficult breast cancers to treat.

In this issue of the Journal of Clinical Investigation, researchers led by Carlos Arteaga at Vanderbilt University identified a protein, TGF-β, that is highly expressed in triple negative breast cancer cells after chemotherapy.

In a mouse model of breast cancer, TGF-β both diverted cells down a path to becoming cancerous and allowed for cancer to come back after treatment. Importantly, loss of TGF-β prevented tumor recurrence in mice. These studies identify a mechanism by which cancer cells elude standard chemotherapy and provide a rationale for testing the therapeutic potential of agents that block TGF-β.

TITLE: TGFβ inhibition enhances chemotherapy action against triple negative breast cancer

View this article at: http://www.jci.org/articles/view/65416?key=201b874c7a54cc627c43

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
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Journal of Clinical Investigation
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Breast Cancer

What Is Breast Cancer?

Breast cancer is a tumor that has become malignant - it has developed from the breast cells. A 'malignant' tumor can spread to other parts of the body - it may also invade surrounding tissue. When it spreads around the body, we call it 'metastasis'. Read more...

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