The First Results Of A Major Scientific Effort To Understand Our Own Ecosystem: The Microbial Communities That Dwell Within Us
"While historically pre and probiotics have dominated the microbiome landscape, emerging data from numerous labs as to the impact of dietary interventions and antibiotic exposure will play formative roles in tailoring therapy," said Kjersti M. Aagaard, M.D., Ph.D., from the Department of Obstetrics and Gynecology at Baylor College of Medicine in Houston, Texas. "We may find that the answers to our most common and prevalent health and disease states lies not in manipulating the human genome, but rather, in utilizing subtle shifts in diet and components of the diet, efficacy trials in prophylactic or preventative antibiotic therapies, and care attention to the over prescription of steroids and antibiotics."
Aagaard and colleagues completed comprehensive body site sampling in healthy 18-40 year old adults, creating an unparalleled reference set of microbiome specimens. Researchers then screened 554 individuals to enroll 300 (149 males, 151 females, mean age 26, mean BMI 24, 20.0 percent racial minority and 10.7 percent Hispanic). Scientists obtained specimens from several body sites to evaluate the longitudinal changes in an individual's microbiome by sampling 279 participants twice (mean 212 days after first sampling, range 30-359), and 100 individuals three times (mean 72 days after second sampling, range 30-224). This sampling strategy yielded 11,174 primary specimens, from which 12,479 DNA samples were submitted to four centers for metagenomic sequencing. This clinical design and well-defined reference cohort has laid a baseline foundation for microbiome research.
"Whether it is yogurt, penicillin, or diet soda, each alters the microbial communities that live within us," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This pioneering study promises to provide their names and numbers, so that we can understand how diet, disease or drugs affect our internal ecosystem."
Kjersti Aagaard, Joseph Petrosino, Wendy Keitel, Mark Watson, James Katancik, Nathalia Garcia, Shital Patel, Mary Cutting, Tessa Madden, Holli Hamilton, Emily Harris, Dirk Gevers, Gina Simone, Pamela McInnes, and James Versalovic. The Human Microbiome Project strategy for comprehensive sampling of the human microbiome and why it matters. FASEB J March 2013 27:1012-1022, doi:10.1096/fj.12-220806; http://www.fasebj.org/content/27/3/1012.abstract.
Federation of American Societies for Experimental Biology
Source: EurekAlert!, the online, global news service operated by AAAS, the science society
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