Innovative Strategy Pinpoints Genes Underlying Cardiovascular Disease Risk
The scientists used a technology called "RNA interference" that can selectively decrease the level of expression of targeted genes. By observing what changes, if any, this decrease causes in cells, researchers can identify the function of the genes and, on a larger scale, objectively test the function of many genes in parallel.
Cholesterol levels in the blood are one of the main risk factors for cardiovascular disease. They are controlled by the amount of cholesterol that cells can take in - thus removing it from the blood - and metabolise. The researchers used RNA interference to test the function of each of the genes within 56 regions previously identified by GWAS as being linked with cardiovascular disease. They selectively decreased their action and measured what, if any, changes this induced in cholesterol metabolism. From this they could deduce which of the genes are most likely to be involved in the onset of the disease.
"This is the first wide-scale RNA interference study that follows up on GWAS. It has proven its potential by narrowing down a large list of candidate genes to the few with an important function that we can now focus on in future in-depth studies," explains Rainer Pepperkok at EMBL, who co-led the study with Heiko Runz at the University of Heidelberg.
"In principle, our approach can be applied to any disease that has an observable effect on cells", adds Heiko Runz. "The genes identified here may further our understanding of the mechanisms leading to cardiovascular disease and allow us to improve its prediction and diagnosis".
Source: EurekAlert!, the online, global news service operated by AAAS, the science society
Please use one of the following formats to cite this article in your essay, paper or report:
European Molecular Biology Laboratory. "Innovative Strategy Pinpoints Genes Underlying Cardiovascular Disease Risk." Medical News Today. MediLexicon, Intl., 4 Mar. 2013. Web.
25 May. 2017. <http://www.medicalnewstoday.com/releases/257082.php>
European Molecular Biology Laboratory. (2013, March 4). "Innovative Strategy Pinpoints Genes Underlying Cardiovascular Disease Risk." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
Contact our news editors
For any corrections of factual information, or to contact our editorial team, please see our contact page.
Copyright Medical News Today: Excluding email/sharing services explicitly offered on this website, material published on Medical News Today may not be reproduced, or distributed without the prior written permission of Medilexicon International Ltd. Please contact us for further details.