Muscle Regeneration Promoted In Mouse Model Of Muscular Dystrophy
In this issue of the Journal of Clinical Investigation, researchers led by Anton Bennett at Yale University identified the protein MKP-5 as a negative regulator of MAP kinase cascades in muscle stem cells. Loss of MKP-5 in a mouse model of DMD enhanced the development of new muscle cells (myogenesis) and helped prevent muscle degeneration. These results identify MKP-5 as an important suppressor of myogenesis and suggest that therapeutics that inhibit MKP-5 could be useful in the treatment of degenerative muscle diseases.
TITLE: Improved regenerative myogenesis and muscular dystrophy in mice lacking MKP-5
View this article at: http://www.jci.org/articles/view/64375?key=bbd026972477a9b98a24
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