Muscle Regeneration Promoted In Mouse Model Of Muscular Dystrophy
In this issue of the Journal of Clinical Investigation, researchers led by Anton Bennett at Yale University identified the protein MKP-5 as a negative regulator of MAP kinase cascades in muscle stem cells. Loss of MKP-5 in a mouse model of DMD enhanced the development of new muscle cells (myogenesis) and helped prevent muscle degeneration. These results identify MKP-5 as an important suppressor of myogenesis and suggest that therapeutics that inhibit MKP-5 could be useful in the treatment of degenerative muscle diseases.
TITLE: Improved regenerative myogenesis and muscular dystrophy in mice lacking MKP-5
View this article at: http://www.jci.org/articles/view/64375?key=bbd026972477a9b98a24
Source: EurekAlert!, the online, global news service operated by AAAS, the science society
Please use one of the following formats to cite this article in your essay, paper or report:
Journal of Clinical Investigation. "Muscle Regeneration Promoted In Mouse Model Of Muscular Dystrophy." Medical News Today. MediLexicon, Intl., 3 Apr. 2013. Web.
9 Dec. 2016. <http://www.medicalnewstoday.com/releases/258486.php>
Journal of Clinical Investigation. (2013, April 3). "Muscle Regeneration Promoted In Mouse Model Of Muscular Dystrophy." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
Contact our news editors
For any corrections of factual information, or to contact our editorial team, please see our contact page.
Copyright Medical News Today: Excluding email/sharing services explicitly offered on this website, material published on Medical News Today may not be reproduced, or distributed without the prior written permission of Medilexicon International Ltd. Please contact us for further details.