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Disclosure: The study was supported by a grant from Pamlab, LLC.
About Pamlab, LLC
Pamlab is a specialty biomedical company that specializes in offering health care providers high quality prescription medical foods to safely address the distinct nutritional requirements of patients suffering from a medical condition.
Deplin® is a medical food containing L-methylfolate, the active form of the vitamin, folate. It is the only folate that can be taken up by the brain where it helps balance the chemical messengers that affect mood (serotonin, norepinephrine and dopamine).
Deplin®, available by prescription, provides the body with the necessary nutritional support to make the brain a better “partner” to the antidepressant a healthcare provider has prescribed.
About Medical Foods
The Orphan Drug Amendments of 1988 define “medical food” as a food which is formulated to be consumed or administered internally under the supervision of a physician and which is intended for the specific dietary management of a disease or condition for which distinctive nutritional requirements, based on recognized scientific principles, are established by medical evaluation.
Deplin® is a registered trademark of Pamlab, LLC
Deplin® a medical food, dispensed by prescription, for the clinical dietary management of the metabolic imbalances associated with depression. Use under medical supervision.
l-Methylfolate as Adjunctive Therapy for SSRI-Resistant Major Depression: Results of Two Randomized, Double-Blind, Parallel-Sequential Trials, George I. Papakostas, M.D.; Richard C. Shelton, M.D.; John M. Zajecka, M.D.; Bijan Etemad, M.D.; Karl Rickels, M.D.; Alisabet Clain, M.S.; Lee Baer, Ph.D.; Elizabeth D. Dalton, B.A.; Garret R. Sacco, B.A.; David Schoenfeld, Ph.D.; Michael Pencina, Ph.D.; Allison Meisner, M.A.; Teodoro Bottiglieri, Ph.D.; Erik Nelson, M.D.; David Mischoulon, M.D., Ph.D.; Jonathan E. Alpert, M.D., Ph.D.; James G. Barbee, M.D.; Sidney Zisook, M.D.; Maurizio Fava, M.D. Am J Psychiatry 2012;169:1267-1274. 10.1176/appi.ajp.2012.11071114
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Depression category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
Pamlab, . "Breakthrough Study Shows Benefits Of Adjunctive L-Methylfolate In The Treatment Of SSRI-Resistant Major Depressive Disorder." Medical News Today. MediLexicon, Intl., 16 Apr. 2013. Web.
10 Mar. 2014. <http://www.medicalnewstoday.com/releases/259117>
Pamlab, . (2013, April 16). "Breakthrough Study Shows Benefits Of Adjunctive L-Methylfolate In The Treatment Of SSRI-Resistant Major Depressive Disorder." Medical News Today. Retrieved from
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