Inflammatory Factors In The Brain May Hold The Key To Depression/Cardiovascular Disease Comorbidity
Dr. Susan K. Wood, a Research Associate at the Children's Hospital of Philadelphia, investigates brain-related biomarkers for depression-heart disease comorbidity. She uses a rodent model of social stress likened to bullying in people that she has found to produce depressive-like behaviors and dysfunctional cardiovascular changes in a susceptible subset of rodents. Her previous work highlighted a role for the stress-related neurohormone corticotropin-releasing factor in rendering an individual vulnerable to stress-induced depression and heart disease. Intrigued by what other biomarkers may be distinct her latest study is the first to identify gene and protein expression differences in the brains of rodents that are either vulnerable or resilient to developing stress-induced depressive-like behaviors and cardiovascular dysfunction.
The study, conducted in male rats, compared expression of 88 genes involved in signaling within the brain between socially stressed and non-stressed rats. It revealed more than 35 genes in stressed rats that had altered expression compared with non-stressed controls. Many of the genes that were differentially expressed were related to inflammation. Follow-up studies measuring protein levels revealed that Interleukin-1β and Monocyte chemotactic protein-1, inflammatory markers known to play a role in depression and heart disease, were suppressed in the brains of the resilient subset of rats and Interleukin-1β was increased in the vulnerable group. Dr. Wood measured the gene and protein levels under resting conditions 24 hours after just 5 daily 30-minute exposures to social stress.
The identification of factors in the brain that distinguish susceptibility and resiliency to depression and heart disease comorbidity would be a major advance in predicting, preventing and treating these disorders. Dr. Wood is continuing these studies as an Assistant Professor at the University of South Carolina School of Medicine with the hope that these findings will uncover new targets to treat the mind and body.
Her findings were presented April 21st, 2013 during Experimental Biology 2013 in Boston, MA.
Source: EurekAlert!, the online, global news service operated by AAAS, the science society
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