No Rebirth For Insulin Secreting Pancreatic Beta Cells
In this issue of the Journal of Clinical Investigation, George Gittes and colleagues at the Children's Hospital of Pittsburgh used a fluorescent cell labeling method in mice to determine exactly when precursor cells develop into pancreatic beta cells. They observed neogenesis during embryonic development, but did not find any evidence of neogenesis in adult mice. These data demonstrate that beta cell neogenesis is not possible in adult mice.
In a companion commentary, Michael German at the University of California, San Francisco, discusses the experiments that will be required to determine if these findings also apply to humans.
TITLE: No evidence for beta cell neogenesis in murine adult pancreas
View this article at: http://www.jci.org/articles/view/66323?key=4eb6fcd0887f4265673b
ACCOMPANYING COMMENTARY TITLE: Anonymous Sources: Where Do Adult β-Cells Come From?
View this article at: http://www.jci.org/articles/view/69297?key=6b064d7e97fbf4fa75a8