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Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss, Proceedings of the National Academy of Sciences DOI: 10.1073/pnas.1306832110.
The study was co-authored by Maria Talantova, Sanford-Burnham; Sara Sanz-Blasco, Sanford-Burnham; Xiaofei Zhang, Sanford-Burnham; Peng Xia, Sanford-Burnham; Mohd Waseem Akhtar, Sanford-Burnham; Shu-ichi Okamoto, Sanford-Burnham; Gustavo Dziewczapolski, Salk Institute; Tomohiro Nakamura, Sanford-Burnham; Gang Cao, Sanford-Burnham; Alexander E. Pratt, Sanford-Burnham and UCSD School of Medicine; Yeon-Joo Kang, Sanford-Burnham; Shichun Tu, Sanford-Burnham; Elena Molokanova, Sanford-Burnham; Scott R. McKercher, Sanford-Burnham; Samuel Andrew Hires, Howard Hughes Medical Research Institute; Hagit Sason, Technion-Israel Institute of Technology; David G. Stouffer, Scripps Research Institute; Matthew W. Buczynski, Scripps Research Institute; James Solomon, Skaggs Institute; Sarah Michael, UCSD School of Medicine; Evan T. Powers, Skaggs Institute; Jeffery W. Kelly, Skaggs Institute; Amanda Roberts, Scripps Research Institute; Gary Tong, Sanford-Burnham; Traci Fang-Newmeyer, Sanford-Burnham; James Parker, Sanford-Burnham; Emily A. Holland, Sanford-Burnham; Dongxian Zhang, Sanford-Burnham; Nobuki Nakanishi, Sanford-Burnham; H.-S. Vincent Chen, Sanford-Burnham; Herman Wolosker, Technion-Israel Institute of Technology; Yuqiang Wang, Jinan University, Guangzhou China and Panorama Research Institute, Sunnyvale, CA; Loren H. Parsons, Scripps Research Institute; Rajesh Ambasudhan, Sanford-Burnham; Eliezer Masliah, UCSD School of Medicine; Stephen F. Heinemann, Salk Institute; Juan C. Piña-Crespo, Sanford-Burnham; and Stuart A. Lipton, Sanford-Burnham.
This research was funded by the U.S. National Institutes of Health (grants P01 AG010436, P50 AG005131, P01 DA017259, R01 AA020404, P01 HD29587, and P01 ES016738), the U.S. Department of Defense (W81XWH-10-1-0093), the National Institute of Neurological Disorders and Stroke Institutional Core (grant P30 NS076411), American Heart Association, and Ministry of Education and Science of Spain.
Sanford-Burnham Medical Research Institute
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
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Sanford-Burnham Medical Research Institute. "New Drug Developed That Reverses Loss Of Brain Connections In Alzheimer's." Medical News Today. MediLexicon, Intl., 19 Jun. 2013. Web.
23 Apr. 2014. <http://www.medicalnewstoday.com/releases/262087>
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