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“The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis”,
Fall T, Hägg S, Mägi R, Ploner A, Fischer K, et al. (2013)
PLoS Med. 10(6): e1001474. doi:10.1371/journal.pmed.1001474
Funding: ENGAGE (European Network for Genetic and Genomic Epidemiology) Consortium, the European Community’s Seventh Framework Programme grant FP7-HEALTH-F4-2007 (201413); Academy of Finland (104781, 120315, 129418, 139635, 141054), Center of Excellence in Complex Disease Genetics (213506, 129680), and SALVE research program (129418, 129494); Australian National Health and Medical Research Council (241944, 339462, 389927, 389875, 389891, 389892, 389938, 442915, 442981, 496739, 552485, 552498); Australian Research Council (A7960034, A79906588, A79801419, DP0770096, DP0212016, DP0343921); Avera Institute, Sioux Falls, South Dakota (USA); Biobanking and Biomolecular Resources Research Infrastructure (BBMRI –NL, 184.021.007); Biotechnology and Biological Sciences Research Council (BBSRC); British Heart Foundation; Center for Medical Systems Biology (CSMB, NOW Genomics); Center of Excellence in Genomics (EXCEGEN); Chronic Disease Research Foundation (CDRF); City of Malmö; Crafoord Foundation; Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy’s & St Thomas’ NHS Foundation Trust in partnership with King’s College London; Development Fund of University of Tartu (SP1GVARENG); Diabetes Programme at the Lund University; Erasmus MC; Erasmus University Rotterdam; Estonian Government (SF0180142s08); Estonian Research Roadmap through Estonian Ministry of Education and Research (3.2.0304.11-0312); Estonian Science Foundation (EstSF ETF9353); EU 5th Framework Programme GenomEUtwin Project (QLG2-CT-2002-01254, EU/QLRT-2001-01254); EU Framework Programme 7 funding stream (IMI SUMMIT); EUR Fellowship; European Commission (EURO-BLCS, Framework 5 award QLG1-CT-2000-0164, FP6 STRP 018947, LSHG-CT-2006- 019473); European Community’s Seventh Framework Program (FP7/2007-2013, CEED3 223211); European Community’s Sixth Framework Programme Cardiogenics project (LSHM-CT-2006-037593); European Foundation for the Study of Diabetes (EFSD); European Science Council (ERC Advanced, 230374); European Science Foundation (ESF, EU/QLRT-2001-01254); European Union (EU/WLRT-2001-01254); EUROSPAN (European Special Populations Research Network); Faculty of Medicine, Lund University; Fellowship Schemes NBIC/BioAssist/RK (2008.024); Finnish Diabetes Research Society; Finnish Foundation for Cardiovascular Research; Folkha¨lsan Research Foundation; Foundation for Life and Health in Finland; Foundation for the US National Institutes of Health; French Institute of Health and Medical Research (U258); Genetic Association Information Network (GAIN); German Federal Ministry of Education and Research (BMBF); German National Genome Research Network (NGFNPlus, 01GS0834); German Research Center for Environmental Health; Guide Dogs for the blind Association(GDBA); Health Administration of Regione Lombardia (9783/1986, 41795/1993, 31737/1997, 17155/2004); Health Informatics Centre; Helmholtz Zentrum München; High Performance Computing Center of University of Tartu; International Agency for Research on Cancer; Internationale Stichting Alzheimer Onderzoek (ISAO); Jakobstad Hospital; K Medical Research Council; Knut and Alice Wallenberg Foundation; LMUinnovativ; Manpei Suzuki Diabetes Foundation; Medical Research Council, UK (G0500539, G0600705, PrevMetSyn/SALVE); Medical Society of Finland; Ministry of Education, Culture and Science, The Netherlands; Ministry of Health Welfare and Sports, The Netherlands; Munich Center of Health Sciences (MC Health); Municipality of Rotterdam; National Cancer Institute (N01-RC-37004); MyEuropia Research Training Network; National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit; National Health and Medical Research Council (NHMRC); National Eye Institute via an NIH/CIDR genotyping project (R01EY018246-01-1 PI: Terri Young); National Institute of Aging (NIA); Netherlands Brain Foundation (HersenStichting Nederland); Netherlands Consortium for Healthy Aging (NCHA); (050-060-810); Netherlands Genomics Initiative (NGI); Netherlands Heart Foundation; Netherlands Organization for Health Research and Development (ZonMw) (10-000-1002, 904-61 090, 985-10-002, 904-61-193, 480-04-004, 400-05-717); Netherlands Organization for Scientific Research (NWO) (175.010.2005.011, 911-03-012, vici, 918-76-619, veni, 916.12.154, Addiction 31160008, Middelgroot-911-09-032, Spinozapremie 56-464-14192); Netherlands Scientific Organization (904-61-090, 904-61-193, 480-04-004, 400-05- 717, I 480-05-003); Neuroscience Campus Amsterdam (NCA); NHLBI (5R01HL087679-02); Novo Nordisk Foundation; Närpes Research Foundation; Ollqvist Foundation; Pfizer Global Research Awards for Nicotine Dependence (GRAND); Pfizer Pharmaceuticals; Påhlsson Foundation; Region Skåne; Research Institute for Diseases in the Elderly (014-93-015; RIDE; RIDE2); Royal Swedish Academy of Sciences; Rutgers University Cell and DNA Repository (NIMH U24 MH068457-06); Seventh Framework Programme ENGAGE project (HEALTH-F4-2007-201413); Signe and Ane Gyllenberg Foundation; Sigrid Juselius Foundation; STAMPEED program (1RL1MH083268-01); Swedish Cancer Society; Swedish Cultural Foundation in Finland; Swedish Diabetes Foundation; Swedish Diabetes Research Society; Swedish Foundation for Strategic Research (SSF; ICA08-0047); Swedish Heart and Lung Foundation; Swedish Medical Research Council; Swedish Ministry for Higher Education; Swedish Research Council for Medicine and Health (Linné grant 349-2008-6589, a strategic SFO grant, Exodiab 2009-1039, M-2005-1112, 2009-2298); Swedish Research Council for Infrastructures; Swedish Society of Medicine; US NIH (AA07535, AA10248, AA11998, AA13320, AA13321, AA13326, AA14041, AA15416, AA17688, DA12854, MH66206, R01D0042157-01A, AG028555, AG08724, AG04563, AG10175, AG08861, R01HL089650-02, DK U01-066134, 5R01MH63706:02, RO1 MH059160, 1RC2MH089951-01, 1RC2 MH089995-01); University Hospital Oulu; University of Dundee; University of Ulm; Uppsala University; Uppsala University Hospital; US National Heart, Lung and Blood Institute; US Public Health Service contracts (N01-CN-45165, N01-RC-45035); Vasa and Närpes Health centers; Wellcome Trust (Biomedical Collections Grant GR072960); Wellcome Trust Sanger Institute; VU University’s Institute for Health and Care Research (EMGO+); TDS is an NIHR senior Investigator and is holder of an ERC Advanced Principal Investigator award; CJH is an NIHR Senior Research Fellow. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing Interests: TF has received honoraria by MSD for lecturing. GT, SG, VS, UT, and KS are employees of deCODE Genetics/Amgen, a biotechnology company. OHF is the recipient of a grant from Pfizer Nutrition to establish a new center of ageing research: ErasmusAGE. KH received funding via the Finnish Academy (grant number 129418). JK holds grants from the EU FP7 (funding the present research and other projects), US NIH, the Academy of Finland, and several Finnish Foundations. JK consulted for Pfizer Inc. in 2012 on nicotine dependence. LG, GDS, and MM are members of the Editorial Board of PLOS Medicine. All other authors have declared that no competing interests exist.
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
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PLoS, . "Causal Relationship Between Adiposity And Heart Failure, And Elevated Liver Enzymes." Medical News Today. MediLexicon, Intl., 25 Jun. 2013. Web.
6 Dec. 2013. <http://www.medicalnewstoday.com/releases/262462>
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