Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
Genetic and biochemical evidence that RNA binding protein, TOP3b, may be a common factor in schizophrenia, autism spectrum disorders, and intellectual impairment is reported by two papers published this week in Nature Neuroscience. Taken together with prior findings that schizophrenia and autism may share common genetic risk factors, these studies identify potential biological processes that may be related to the cognitive deficits shared by these disorders.
Due to migration patterns over the centuries, a region in Northern Finland has a high incidence of schizophrenia. By studying this population, Nelson Freimer, Utz Fischer and colleagues found that some of these individuals carry a small deletion in their genomes that includes the gene TOP3b and that this mutation increases the risk for cognitive impairment and schizophrenia.
In an independent study, Weidong Wang, Sige Zou and colleagues report that the TOP3b protein binds to and unwinds RNA and that this process depends on interactions with another RNA binding protein, FMRP. The gene encoding the FRMP protein is mutated in Fragile X syndrome, a disorder that often includes the presence of intellectual disability and autism. Wang and Zou's team also showed that many of the RNAs bound by FMRP were also bound by TOP3b and that similar to mutations in FMRP, mutations of TOP3b caused abnormal synapse development in flies and mice.
Nature Neuroscience DOI: 10.1038/nn.3484
Nature Neuroscience DOI: 10.1038/nn.3479
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Neurology / Neuroscience category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
Nature. "Mutation links intellectual impairment, schizophrenia and autism." Medical News Today. MediLexicon, Intl., 4 Aug. 2013. Web.
23 Apr. 2014. <http://www.medicalnewstoday.com/releases/264167>
Nature. (2013, August 4). "Mutation links intellectual impairment, schizophrenia and autism." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/264167.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2014 All rights reserved. MNT is the registered trade mark of MediLexicon International Limited.