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Chronic obstructive pulmonary disease (COPD) is characterized by poor airflow due to the breakdown of lung tissue, mucus accumulation and airway dysfunction. Development of COPD is most commonly associated with smoking tobacco, however, it also occurs after acute respiratory infections such as influenza. It is unclear how prior lung disease leads to COPD.
In the current issue of the Journal of Clinical Investigation, Michael Holtzman and colleagues at the Washington University School of Medicine report that expression of an inflammatory molecule, interleukin-33 (IL-33), is increased in the airways of both a mouse model of viral-induced COPD and humans with COPD. Increased IL-33 was associated with an increase in mucus production, and expression of other COPD-implicated genes.
The authors found in their mouse model that expression of the gene encoding IL-33 was localized to a population of lungs cells that were induced in the airway after viral infection. These results lay the groundwork for potential therapeutic strategies aimed at preventing COPD after acute lung infection.
J Clin Invest. doi:10.1172/JCI65570.
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
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Journal of Clinical Investigation. "Inflammatory molecule involved in development of chronic obstructive pulmonary disease." Medical News Today. MediLexicon, Intl., 18 Aug. 2013. Web.
10 Dec. 2013. <http://www.medicalnewstoday.com/releases/264914>
Journal of Clinical Investigation. (2013, August 18). "Inflammatory molecule involved in development of chronic obstructive pulmonary disease." Medical News Today. Retrieved from
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